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| League History Index | Players | Teams | Managers | Leagues | Leaderboards | Awards | Accomplishments |
| Rank | Player | OAVG | YEAR | Open Career Leaderboard |
|---|---|---|---|---|
| 1 | Gilberto Martínez# | .1434 | 2029 | |
| 2 | Archie Esparza# | .1494 | 2027 | |
| 3 | Archie Esparza# | .1792 | 2029 | |
| 4 | Archie Esparza# | .1831 | 2028 | |
| 5 | Scott Sanders | .1839 | 1996 | |
| 6 | Gregory Burke | .1842 | 2006 | |
| 7 | Roger Clemens* | .1854 | 1986 | |
| 8 | Gilberto Martínez# | .1856 | 2028 | |
| 9 | Kerry Wood | .1869 | 2002 | |
| 10 | Kerry Wood | .1873 | 2003 | |
| 11 | Kerry Wood | .1876 | 1999 | |
| 12 | Kerry Wood | .1900 | 2006 | |
| 13 | Bob Jenkins* | .1904 | 2020 | |
| 14 | Javier Vazquez* | .1910 | 2002 | |
| 15 | Roger Clemens* | .1914 | 1987 | |
| 16 | Dave Dowden | .1916 | 2023 | |
| 17 | Archie Esparza# | .1926 | 2026 | |
| 18 | William Pierce# | .1939 | 2027 | |
| 19 | Pedro López# | .1940 | 2022 | |
| 20 | Michael Hood | .1941 | 2010 | |
| 21 | Scott Kazmir | .1947 | 2009 | |
| 22 | Randy D Johnson | .1955 | 1991 | |
| 23 | Daron Maddox | .1963 | 2019 | |
| 24 | Randy D Johnson | .1966 | 1990 | |
| 25 | Gregory Burke | .1968 | 2007 | |
| 26 | Roger Clemens* | .1971 | 2000 | |
| 26 | Randy D Johnson | .1971 | 1998 | |
| 28 | Daron Maddox | .1972 | 2015 | |
| 29 | Bob Jenkins* | .1974 | 2012 | |
| 30 | Gilberto Martínez# | .1975 | 2027 | |
| 31 | Gregory Burke | .1983 | 2008 | |
| 32 | Bob Jenkins* | .1995 | 2011 | |
| 32 | Kevin Schaefer | .1995 | 2015 | |
| 34 | Roger Clemens* | .1996 | 1990 | |
| 34 | Clarence Holland | .1996 | 2015 | |
| 36 | Joe Sparks | .1997 | 2013 | |
| 37 | Matthew Trantham | .2003 | 2023 | |
| 38 | Joba Chamberlain | .2007 | 2015 | |
| 39 | Toki Nagai | .2008 | 2007 | |
| 40 | Mark Prior* | .2012 | 2002 | |
| 41 | Joe Sparks | .2013 | 2015 | |
| 42 | Ugueth Urbina | .2017 | 1997 | |
| 43 | Roger Clemens* | .2025 | 1992 | |
| 44 | Carlos Zambrano | .2026 | 2011 | |
| 45 | James Ryan# | .2029 | 2021 | |
| 46 | Carlos Jiménez# | .2040 | 2023 | |
| 47 | Nolan Arnold | .2041 | 2015 | |
| 48 | A J Burnett | .2049 | 2002 | |
| 49 | John Fletcher# | .2050 | 2026 | |
| 49 | Ramon J Martinez | .2050 | 1988 | |
| 51 | Raimondo Amberezzio# | .2052 | 2028 | |
| 51 | Carl Pavano | .2052 | 2008 | |
| 53 | António Ortíz | .2053 | 2005 | |
| 54 | James Ryan# | .2058 | 2020 | |
| 54 | Juan Guzman* | .2058 | 1993 | |
| 56 | Allen Bailey | .2060 | 2015 | |
| 57 | Mark Prior* | .2062 | 2015 | |
| 57 | Dwight Tucker | .2062 | 2015 | |
| 59 | Rick Snow# | .2064 | 2027 | |
| 60 | Gil Meche | .2067 | 2001 | |
| 61 | Victor Moret | .2068 | 2004 | |
| 62 | Dwight Tucker | .2072 | 2013 | |
| 63 | Mark Prior* | .2077 | 2003 | |
| 63 | Kevin Walters | .2077 | 2005 | |
| 65 | Javier Vazquez* | .2080 | 2003 | |
| 66 | Scott Kazmir | .2081 | 2013 | |
| 66 | Fernando Montero# | .2081 | 2029 | |
| 68 | Eddie Morgan* | .2082 | 2008 | |
| 69 | Luis Vigil# | .2083 | 2023 | |
| 70 | Toki Nagai | .2085 | 2010 | |
| 71 | Mark Prior* | .2086 | 2004 | |
| 71 | Dorian Bunch# | .2086 | 2023 | |
| 73 | Kerry Wood | .2087 | 1998 | |
| 74 | Rafael Hernández# | .2088 | 2024 | |
| 75 | Mark Prior* | .2089 | 2007 | |
| 76 | Stephen Strasburg | .2091 | 2017 | |
| 76 | Raúl López | .2091 | 2003 | |
| 76 | Rick Snow# | .2091 | 2028 | |
| 79 | Nolan Arnold | .2092 | 2013 | |
| 80 | Bartolo Colon | .2094 | 1998 | |
| 80 | Roger Clemens* | .2094 | 1991 | |
| 80 | Rick Snow# | .2094 | 2026 | |
| 83 | Gregory Burke | .2100 | 2009 | |
| 83 | Eddie Morgan* | .2100 | 2009 | |
| 85 | Mark Prior* | .2101 | 2006 | |
| 86 | Roy Oswalt* | .2103 | 2012 | |
| 87 | Roy Ward | .2105 | 2015 | |
| 88 | Allan Arbogast# | .2107 | 2031 | |
| 89 | Dan Wilkerson# | .2109 | 2029 | |
| 90 | Steve Watts | .2110 | 2011 | |
| 91 | R A Dickey | .2112 | 2003 | |
| 91 | Jesse Foppert | .2112 | 2006 | |
| 91 | Bob Jenkins* | .2112 | 2014 | |
| 94 | Hideo Nomo | .2114 | 2000 | |
| 95 | Gilberto Martínez# | .2115 | 2030 | |
| 95 | Ebby Calvin LaLoosh | .2115 | 2012 | |
| 97 | José Torres# | .2117 | 2029 | |
| 98 | James Ryan# | .2118 | 2023 | |
| 99 | Gary Lefebvre | .2119 | 2008 | |
| 100 | Mark Prior* | .2123 | 2005 |
