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| League History Index | Players | Teams | Managers | Leagues | Leaderboards | Awards | Accomplishments |
| Rank | Player | BB | YEAR | Open Career Leaderboard |
|---|---|---|---|---|
| 1 | James West | 164 | 2009 | |
| 2 | Hideo Nomo | 136 | 1998 | |
| 3 | Rich Harden | 134 | 2006 | |
| 4 | A J Burnett | 133 | 2001 | |
| 5 | Mark Prior* | 129 | 2010 | |
| 5 | Mark Prior* | 129 | 2011 | |
| 7 | Kyle Jones | 128 | 2016 | |
| 8 | Ryan Bowen | 127 | 1998 | |
| 9 | Jason Ellis | 126 | 2016 | |
| 9 | Terrence Duffy | 126 | 2014 | |
| 11 | Yovani Gallardo | 125 | 2018 | |
| 12 | Jay Slooters# | 124 | 2029 | |
| 12 | Will Terry | 124 | 2016 | |
| 14 | Rafael Hernández# | 123 | 2024 | |
| 14 | Joey Hamilton | 123 | 2006 | |
| 14 | Dirk Von Hayhurst | 123 | 2015 | |
| 17 | José Escamilla | 122 | 2013 | |
| 17 | Mark Prior* | 122 | 2013 | |
| 19 | Joe Bailey | 120 | 2017 | |
| 20 | Hideo Nomo | 118 | 1999 | |
| 20 | Malcolm Zegwaard | 118 | 2017 | |
| 22 | Michael MacInally | 117 | 2004 | |
| 23 | Yovani Gallardo | 116 | 2015 | |
| 24 | Kerry Wood | 115 | 2007 | |
| 24 | Will Davidson | 115 | 2011 | |
| 24 | Allen Bailey | 115 | 2012 | |
| 27 | Aidan Kendal | 114 | 2017 | |
| 27 | Willie Nicholson | 114 | 2017 | |
| 27 | Hideo Nomo | 114 | 2002 | |
| 30 | Willie Banks | 113 | 1997 | |
| 30 | Ryan Bowen | 113 | 1997 | |
| 32 | Cliff P Lee | 112 | 2005 | |
| 32 | José Escamilla | 112 | 2014 | |
| 32 | Jeff Sawyer | 112 | 2013 | |
| 32 | Will Terry | 112 | 2015 | |
| 36 | Kazuhisa Ishii | 111 | 2010 | |
| 36 | Will Davidson | 111 | 2010 | |
| 36 | Edinson Volquez | 111 | 2011 | |
| 39 | Mal López | 110 | 2006 | |
| 39 | Kerry Wood | 110 | 1998 | |
| 39 | Ariel Prieto | 110 | 1996 | |
| 39 | Joaquin Benoit | 110 | 2002 | |
| 39 | Randy D Johnson | 110 | 1992 | |
| 44 | A J Burnett | 109 | 2006 | |
| 44 | Juan Vega | 109 | 2020 | |
| 44 | Ramon J Martinez | 109 | 1988 | |
| 44 | A J Burnett | 109 | 2009 | |
| 48 | A J Burnett | 108 | 2000 | |
| 48 | Chuck Smith | 108 | 2001 | |
| 48 | Barry Zito | 108 | 2001 | |
| 48 | Ryan Dempster | 108 | 2004 | |
| 48 | Will Terry | 108 | 2017 | |
| 53 | Jeremy Bonderman | 107 | 2005 | |
| 53 | Lance Lynn | 107 | 2015 | |
| 53 | Phil Barnes | 107 | 2010 | |
| 53 | Tim McJannett | 107 | 2016 | |
| 53 | Hideo Nomo | 107 | 2000 | |
| 53 | Juan Guzman* | 107 | 1992 | |
| 53 | Freddy Garcia | 107 | 2002 | |
| 53 | Willie Nicholson | 107 | 2016 | |
| 53 | Juan Guzman* | 107 | 1991 | |
| 62 | Jeff Sawyer | 106 | 2008 | |
| 62 | A J Burnett | 106 | 2007 | |
| 62 | Jesse Foppert | 106 | 2010 | |
| 65 | Eric Gagne | 105 | 2000 | |
| 65 | Doug Fister | 105 | 2015 | |
| 65 | Jeff Samardzija | 105 | 2010 | |
| 65 | Kerry Wood | 105 | 2003 | |
| 65 | Keith Dent | 105 | 2011 | |
| 65 | Chris R Young | 105 | 2016 | |
| 65 | Juan Vega | 105 | 2022 | |
| 72 | Dennys Reyes | 104 | 1998 | |
| 72 | Dennys Reyes | 104 | 2003 | |
| 72 | Jon Garland | 104 | 2004 | |
| 72 | Ryan Dempster | 104 | 2002 | |
| 76 | Malcolm Zegwaard | 103 | 2016 | |
| 76 | Francisco Rodriguez | 103 | 2007 | |
| 76 | Scott Kazmir | 103 | 2014 | |
| 76 | Dirk Von Hayhurst | 103 | 2016 | |
| 76 | Scott Kazmir | 103 | 2013 | |
| 76 | Gio Gonzalez | 103 | 2015 | |
| 76 | A J Burnett | 103 | 2003 | |
| 83 | Doug Jones | 102 | 2012 | |
| 83 | Dennys Reyes | 102 | 2002 | |
| 83 | Gio Gonzalez | 102 | 2019 | |
| 83 | Abraham Hoover | 102 | 2015 | |
| 87 | Jason Yoder | 101 | 2020 | |
| 87 | Matt Clement | 101 | 1998 | |
| 87 | Kerry Wood | 101 | 2006 | |
| 87 | Ryan Bowen | 101 | 1996 | |
| 87 | Dirk Von Hayhurst | 101 | 2014 | |
| 92 | Dontrelle Willis | 100 | 2007 | |
| 92 | Omar Ángel | 100 | 2004 | |
| 92 | Andre Hesketh# | 100 | 2026 | |
| 92 | Juan Guzman* | 100 | 1997 | |
| 92 | Rick Lamb | 100 | 2014 | |
| 92 | Vinnie Baker | 100 | 2007 | |
| 92 | Lance Lynn | 100 | 2016 | |
| 92 | Rich Harden | 100 | 2005 | |
| 100 | Jorge Enríquez# | 99 | 2021 |
