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| League History Index | Players | Teams | Managers | Leagues | Leaderboards | Awards | Accomplishments |
| Rank | Player | IP | YEAR | Open Career Leaderboard |
|---|---|---|---|---|
| 1 | Scott Erickson | 251.0 | 1998 | |
| 2 | Pedro Martinez# | 249.0 | 2002 | |
| 2 | Roy Oswalt# | 249.0 | 2002 | |
| 4 | Greg Maddux# | 248.0 | 2001 | |
| 5 | CC Sabathia# | 247.0 | 2003 | |
| 5 | Mike Mussina# | 247.0 | 2002 | |
| 7 | Jaime Navarro | 246.0 | 1992 | |
| 8 | Curt Schilling# | 245.0 | 2001 | |
| 8 | CC Sabathia# | 245.0 | 2002 | |
| 10 | Brian Lawrence# | 244.0 | 2003 | |
| 11 | Johan Santana# | 243.0 | 2002 | |
| 12 | Mark Mulder# | 242.0 | 2002 | |
| 12 | Brian Lawrence# | 242.0 | 2002 | |
| 12 | Pedro Martinez# | 242.0 | 2001 | |
| 12 | Pedro Martinez# | 242.0 | 2003 | |
| 16 | Kevin Brown# | 241.0 | 2001 | |
| 17 | Curt Schilling# | 240.0 | 2002 | |
| 17 | Roy Halladay# | 240.0 | 2001 | |
| 17 | Mark Buehrle# | 240.0 | 2002 | |
| 20 | Javier Vazquez# | 239.0 | 2001 | |
| 20 | Randy Johnson# | 239.0 | 2001 | |
| 20 | Mark Buehrle# | 239.0 | 2003 | |
| 23 | John Smoltz# | 238.0 | 2001 | |
| 23 | Roy Oswalt# | 238.0 | 2003 | |
| 25 | Jaime Navarro | 236.0 | 1996 | |
| 25 | Freddy Garcia# | 236.0 | 2002 | |
| 25 | Barry Zito# | 236.0 | 2002 | |
| 25 | Tim Hudson# | 236.0 | 2001 | |
| 29 | Greg Maddux# | 235.0 | 2002 | |
| 30 | Mike Mussina# | 234.0 | 2001 | |
| 30 | Jake Peavy# | 234.0 | 2003 | |
| 30 | Jaime Navarro | 234.0 | 1991 | |
| 33 | Steve Avery | 233.0 | 1992 | |
| 33 | Jon Lieber# | 233.0 | 2003 | |
| 33 | John Smoltz# | 233.0 | 2002 | |
| 33 | Mark Mulder# | 233.0 | 2003 | |
| 33 | Jason Schmidt# | 233.0 | 2001 | |
| 33 | Javier Vazquez# | 233.0 | 2002 | |
| 33 | Brad Penny# | 233.0 | 2003 | |
| 40 | Freddy Garcia# | 232.0 | 2001 | |
| 41 | Odalis Perez# | 231.0 | 2002 | |
| 41 | Mark Prior# | 231.0 | 2003 | |
| 41 | Jason Schmidt# | 231.0 | 2003 | |
| 41 | Jon Lieber# | 231.0 | 2002 | |
| 41 | Randy Wolf# | 231.0 | 2001 | |
| 46 | Scott Erickson | 230.0 | 1999 | |
| 46 | Curt Schilling# | 230.0 | 2003 | |
| 46 | Freddy Garcia# | 230.0 | 2003 | |
| 49 | Javier Vazquez# | 229.0 | 2003 | |
| 49 | Jason Schmidt# | 229.0 | 2002 | |
| 49 | Brian Lawrence# | 229.0 | 2001 | |
| 52 | Randy Johnson# | 228.0 | 2002 | |
| 52 | Kevin Brown# | 228.0 | 2002 | |
| 52 | Tim Hudson# | 228.0 | 2003 | |
| 52 | Joel Pineiro# | 228.0 | 2003 | |
| 52 | Andy Pettitte# | 228.0 | 2002 | |
| 52 | Chris Haney | 228.0 | 1996 | |
| 58 | Randy Wolf# | 227.0 | 2002 | |
| 58 | Matt Morris# | 227.0 | 2002 | |
| 60 | Barry Zito# | 226.0 | 2003 | |
| 60 | Greg Maddux# | 226.0 | 2003 | |
| 60 | Derek Lowe# | 226.0 | 2003 | |
| 60 | Odalis Perez# | 226.0 | 2001 | |
| 60 | John Thomson# | 226.0 | 2001 | |
| 65 | Joel Pineiro# | 225.0 | 2001 | |
| 65 | Cory Lidle# | 225.0 | 2003 | |
| 65 | Derek Lowe# | 225.0 | 2001 | |
| 65 | Runelvys Hernandez# | 225.0 | 2003 | |
| 69 | Andy Pettitte# | 224.0 | 2003 | |
| 69 | Mark Buehrle# | 224.0 | 2001 | |
| 69 | Mark Mulder# | 224.0 | 2001 | |
| 69 | Jose Guzman | 224.0 | 1992 | |
| 69 | Mark Redman# | 224.0 | 2001 | |
| 74 | Mark Redman# | 223.0 | 2002 | |
| 74 | Wade Miller# | 223.0 | 2002 | |
| 74 | Steve Avery | 223.0 | 1993 | |
| 74 | Justin W. Thompson | 223.0 | 1997 | |
| 74 | Todd Stottlemyre | 223.0 | 1996 | |
| 74 | Kerry Wood# | 223.0 | 2002 | |
| 80 | Derek Lowe# | 222.0 | 2002 | |
| 80 | Jon Lieber# | 222.0 | 2001 | |
| 80 | Scott Erickson | 222.0 | 1996 | |
| 80 | Justin W. Thompson | 222.0 | 1998 | |
| 80 | Mike Mussina# | 222.0 | 2003 | |
| 85 | Todd Stottlemyre | 221.0 | 1998 | |
| 85 | Scott Erickson | 221.0 | 1997 | |
| 85 | Bartolo Colon# | 221.0 | 2001 | |
| 85 | Matt Morris# | 221.0 | 2003 | |
| 89 | Randy Wolf# | 220.0 | 2003 | |
| 89 | Brian Tollberg# | 220.0 | 2003 | |
| 91 | Tom Gordon# | 219.0 | 2001 | |
| 91 | Mark Redman# | 219.0 | 2003 | |
| 91 | Todd Stottlemyre | 219.0 | 1991 | |
| 94 | Scott Erickson | 218.0 | 1993 | |
| 94 | Kevin Millwood# | 218.0 | 2003 | |
| 94 | Jamie Moyer | 218.0 | 2001 | |
| 94 | John Lackey# | 218.0 | 2002 | |
| 94 | Josh Beckett# | 218.0 | 2002 | |
| 99 | Kris Benson# | 217.0 | 2000 | |
| 100 | Andy Pettitte# | 216.0 | 2001 |
