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| League History Index | Players | Teams | Managers | Leagues | Leaderboards | Awards | Accomplishments |
| Rank | Player | IP | YEAR | Open Season Leaderboard |
|---|---|---|---|---|
| 1 | Roger Clemens* | 4812.0 | 1984-2006 | |
| 2 | Brandon Webb* | 4031.0 | 2004-2024 | |
| 3 | David Nied* | 3674.0 | 1992-2009 | |
| 4 | Josh Beckett* | 3648.0 | 2001-2020 | |
| 5 | Hipolito Pichardo | 3411.0 | 1992-2008 | |
| 6 | Brett Myers | 3369.0 | 2002-2017 | |
| 7 | Cole Hamels* | 3333.0 | 2007-2023 | |
| 8 | Reece MacKinley | 3314.0 | 2007-2024 | |
| 9 | CC Sabathia* | 3217.0 | 2001-2019 | |
| 10 | John Smoltz | 3205.0 | 1988-2003 | |
| 11 | Madison Bumgarner | 3194.0 | 2014-2031 | |
| 12 | Zack Greinke* | 3172.0 | 2005-2020 | |
| 13 | Ismael Valdez* | 3149.0 | 1994-2010 | |
| 14 | Steve Karsay | 3099.0 | 1993-2007 | |
| 15 | Tim Lincecum | 3046.0 | 2009-2025 | |
| 16 | Roy Oswalt* | 2983.0 | 2001-2016 | |
| 17 | Chad Billingsley | 2962.0 | 2008-2024 | |
| 18 | Scott Sanders | 2936.0 | 1993-2007 | |
| 19 | Javier Vazquez* | 2915.0 | 1998-2013 | |
| 20 | Dwight Tucker | 2914.0 | 2011-2027 | |
| 21 | Mark Prior* | 2902.0 | 2002-2016 | |
| 22 | Gil Meche | 2874.0 | 1999-2014 | |
| 23 | Juan Guzman* | 2861.0 | 1991-2005 | |
| 24 | Jon Lieber | 2846.0 | 1994-2009 | |
| 25 | Randy Tomlin | 2833.0 | 1990-2005 | |
| 26 | Bob Jenkins* | 2813.0 | 2008-2023 | |
| 27 | R A Dickey | 2789.0 | 2002-2018 | |
| 28 | Eddie Morgan* | 2770.0 | 2005-2019 | |
| 29 | Major Pixel | 2768.0 | 2007-2021 | |
| 30 | Stephen Strasburg | 2761.0 | 2011-2027 | |
| 31 | Johan Santana | 2710.0 | 2000-2015 | |
| 32 | Rheal Cormier | 2709.0 | 1991-2005 | |
| 33 | Kyle Sackett | 2704.0 | 2000-2015 | |
| 34 | Randy Wolf | 2694.0 | 1999-2013 | |
| 35 | Bartolo Colon | 2691.0 | 1997-2011 | |
| 36 | Aaron Sele* | 2685.0 | 1993-2006 | |
| 37 | George Connolly# | 2670.0 | 2018-2031 | |
| 38 | Joba Chamberlain | 2600.0 | 2012-2027 | |
| 39 | Lee Myers# | 2597.0 | 2019-2031 | |
| 40 | Carl Pavano | 2590.0 | 1998-2012 | |
| 41 | Jason Ellis | 2580.0 | 2013-2027 | |
| 42 | Ignacio Rodríguez | 2567.0 | 2002-2015 | |
| 43 | Andy Ashby | 2531.0 | 1991-2002 | |
| 44 | Gary Lefebvre | 2529.0 | 2002-2016 | |
| 45 | Ramon J Martinez | 2527.0 | 1988-2002 | |
| 46 | Raúl López | 2519.0 | 2000-2016 | |
| 47 | Steve Woodard | 2514.0 | 1997-2014 | |
| 48 | Jerry Burrell# | 2509.0 | 2016-2031 | |
| 49 | Roy Halladay* | 2507.0 | 1998-2014 | |
| 50 | Matthew Trantham | 2471.0 | 2015-2029 | |
| 51 | Steve Nebraska | 2459.0 | 2005-2018 | |
| 52 | Jimmy Anderson | 2449.0 | 1999-2011 | |
| 53 | Brad Radke | 2441.0 | 1995-2007 | |
| 54 | Simon Duncombe | 2428.0 | 2002-2017 | |
| 55 | Allen Bailey | 2403.0 | 2011-2023 | |
| 56 | Roy Ward | 2402.0 | 2014-2026 | |
| 57 | Kevin Millwood | 2371.0 | 1997-2011 | |
| 58 | Eric Hurley | 2369.0 | 2007-2020 | |
| 59 | Chris R Young | 2352.0 | 2004-2016 | |
| 60 | Jake Peavy | 2344.0 | 2002-2017 | |
| 61 | Carlos Zambrano | 2327.0 | 2001-2019 | |
| 62 | Randy D Johnson | 2321.0 | 1988-2003 | |
| 63 | Jorge Enríquez# | 2316.0 | 2020-2031 | |
| 64 | Chris Carpenter | 2309.0 | 1997-2009 | |
| 65 | Nolan Arnold | 2305.0 | 2011-2022 | |
| 66 | Tom Glavine | 2301.0 | 1987-2003 | |
| 67 | Aaron Harang | 2298.0 | 2003-2017 | |
| 68 | Ben Sheets | 2297.0 | 2001-2015 | |
| 69 | Barry Zito | 2280.0 | 2000-2014 | |
| 70 | Matt Cain | 2279.0 | 2007-2020 | |
| 71 | A J Burnett | 2271.0 | 1999-2010 | |
| 72 | Alex Fernandez | 2266.0 | 1990-2004 | |
| 73 | Adam Wainwright | 2260.0 | 2009-2024 | |
| 74 | Anthony Hunt | 2251.0 | 2016-2028 | |
| 75 | Ryan Bowen | 2230.0 | 1992-2005 | |
| 76 | Michael Hood | 2228.0 | 2002-2013 | |
| 77 | Joe Mays | 2226.0 | 1999-2011 | |
| 78 | Brandon Duckworth | 2225.0 | 2001-2011 | |
| 79 | Dick Hulse | 2214.0 | 2009-2021 | |
| 80 | Paul Phelps | 2204.0 | 2014-2026 | |
| 81 | Josh England | 2183.0 | 2008-2019 | |
| 82 | Cliff P Lee | 2182.0 | 2003-2015 | |
| 83 | Eduard Fotachi# | 2177.0 | 2019-2031 | |
| 84 | Julián Martínez | 2172.0 | 2007-2019 | |
| 85 | Manny Aybar | 2168.0 | 1997-2008 | |
| 86 | Bud Smith | 2148.0 | 2001-2014 | |
| 87 | Alan Benes | 2144.0 | 1995-2006 | |
| 88 | Scott Kazmir | 2139.0 | 2004-2019 | |
| 89 | Roger Bailey | 2081.0 | 2003-2014 | |
| 89 | Micah Olson# | 2081.0 | 2016-2031 | |
| 91 | Jeff Neal# | 2069.0 | 2019-2031 | |
| 91 | Bob Clark | 2069.0 | 2001-2015 | |
| 91 | Jeff Samardzija | 2069.0 | 2009-2021 | |
| 94 | Jerry Patterson | 2048.0 | 2002-2015 | |
| 95 | Joey Hamilton | 2035.0 | 1994-2007 | |
| 96 | Mark Buehrle | 2032.0 | 2000-2016 | |
| 97 | Toki Nagai | 2028.0 | 2004-2015 | |
| 98 | Mark Mulder | 2013.0 | 2000-2015 | |
| 99 | Keith McCoy# | 2011.0 | 2020-2031 | |
| 100 | Tony Martínez | 1988.0 | 2002-2012 |
