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| League History Index | Players | Teams | Managers | Leagues | Leaderboards | Awards | Accomplishments |
| Rank | Player | IP | YEAR | Open Season Leaderboard |
|---|---|---|---|---|
| 1 | Todd Stottlemyre | 2171.0 | 1988-2000 | |
| 2 | Scott Erickson | 2106.0 | 1990-2000 | |
| 3 | Jaime Navarro | 2055.0 | 1989-2000 | |
| 4 | Steve Avery | 1538.0 | 1990-1999 | |
| 5 | Jose Guzman | 1224.0 | 1985-1994 | |
| 6 | Kent Mercker | 1152.0 | 1989-2003 | |
| 7 | Donovan Osborne# | 867.0 | 1992-2002 | |
| 8 | Chris Haney | 812.0 | 1991-2002 | |
| 9 | Pedro Martinez# | 733.0 | 2001-2003 | |
| 10 | Brian Lawrence# | 716.0 | 2001-2003 | |
| 10 | Curt Schilling# | 716.0 | 2001-2003 | |
| 12 | Greg Maddux# | 710.0 | 2001-2003 | |
| 13 | Mike Mussina# | 703.0 | 2001-2003 | |
| 13 | Mark Buehrle# | 703.0 | 2001-2003 | |
| 15 | Javier Vazquez# | 702.0 | 2001-2003 | |
| 16 | Darren Holmes# | 700.0 | 1990-2003 | |
| 16 | Mark Mulder# | 700.0 | 2001-2003 | |
| 18 | Freddy Garcia# | 699.0 | 2001-2003 | |
| 19 | CC Sabathia# | 697.0 | 2001-2003 | |
| 20 | Jason Schmidt# | 694.0 | 2001-2003 | |
| 21 | Jon Lieber# | 687.0 | 2001-2003 | |
| 22 | Kevin Brown# | 683.0 | 2001-2003 | |
| 23 | Scott Sanders | 681.0 | 1993-1999 | |
| 24 | Tim Hudson# | 679.0 | 2001-2003 | |
| 25 | Randy Wolf# | 678.0 | 2001-2003 | |
| 26 | Derek Lowe# | 674.0 | 2001-2003 | |
| 27 | Randy Johnson# | 673.0 | 2001-2003 | |
| 28 | Odalis Perez# | 672.0 | 2001-2003 | |
| 28 | Kris Benson# | 672.0 | 1999-2003 | |
| 28 | Roy Oswalt# | 672.0 | 2001-2003 | |
| 31 | Barry Zito# | 670.0 | 2001-2003 | |
| 32 | Andy Pettitte# | 668.0 | 2001-2003 | |
| 33 | Mark Redman# | 667.0 | 2001-2003 | |
| 33 | Mel Rojas | 667.0 | 1990-1999 | |
| 35 | Matt Morris# | 658.0 | 2001-2003 | |
| 36 | Jake Peavy# | 655.0 | 2001-2003 | |
| 37 | John Smoltz# | 653.0 | 2001-2003 | |
| 38 | Justin W. Thompson | 647.0 | 1996-1999 | |
| 39 | John Lackey# | 639.0 | 2001-2003 | |
| 40 | Joel Pineiro# | 635.0 | 2001-2003 | |
| 41 | Adam Eaton# | 633.0 | 2001-2003 | |
| 41 | Eric Milton# | 633.0 | 2001-2003 | |
| 43 | Brad Radke# | 632.0 | 2001-2003 | |
| 44 | Brad Penny# | 630.0 | 2001-2003 | |
| 44 | Kevin Millwood# | 630.0 | 2001-2003 | |
| 46 | Jeff Weaver# | 627.0 | 2001-2003 | |
| 47 | Kerry Wood# | 615.0 | 2001-2003 | |
| 48 | Wade Miller# | 611.0 | 2001-2003 | |
| 49 | Bartolo Colon# | 609.0 | 2001-2003 | |
| 49 | Paul Wilson# | 609.0 | 2001-2003 | |
| 51 | Glendon Rusch# | 606.0 | 2001-2003 | |
| 52 | Al Leiter# | 603.0 | 2001-2003 | |
| 53 | Tom Gordon# | 602.0 | 2001-2003 | |
| 54 | Russ Ortiz# | 601.0 | 2001-2003 | |
| 55 | Josh Beckett# | 599.0 | 2001-2003 | |
| 56 | Chan-ho Park# | 594.0 | 2001-2003 | |
| 57 | Doug Davis# | 593.0 | 2001-2003 | |
| 58 | Roy Halladay# | 592.0 | 2001-2003 | |
| 59 | Tony Armas# | 590.0 | 2001-2003 | |
| 60 | Darryl Kile# | 587.0 | 2001-2003 | |
| 61 | Rick Reed# | 586.0 | 2001-2003 | |
| 62 | Runelvys Hernandez# | 584.0 | 2001-2003 | |
| 63 | Sterling Hitchcock# | 579.0 | 2001-2003 | |
| 64 | Jarrod Washburn# | 578.0 | 2001-2003 | |
| 64 | Sidney Ponson# | 578.0 | 2001-2003 | |
| 66 | Bud Smith# | 576.0 | 2001-2003 | |
| 67 | Shawn Estes# | 572.0 | 2001-2003 | |
| 68 | Kelvim Escobar# | 569.0 | 2001-2003 | |
| 69 | Ben Sheets# | 568.0 | 2001-2003 | |
| 70 | Matt Clement# | 567.0 | 2001-2003 | |
| 70 | Cory Lidle# | 567.0 | 2001-2003 | |
| 72 | Ryan Rupe# | 561.0 | 2001-2003 | |
| 73 | Johan Santana# | 547.0 | 2001-2003 | |
| 74 | Kip Wells# | 546.0 | 2001-2003 | |
| 75 | Rick Helling# | 543.0 | 2001-2003 | |
| 76 | Brandon Duckworth# | 539.0 | 2001-2003 | |
| 77 | Mike Thurman# | 538.0 | 2001-2003 | |
| 77 | Dave Burba# | 538.0 | 2001-2003 | |
| 79 | A.J. Burnett# | 532.0 | 2001-2003 | |
| 79 | John Thomson# | 532.0 | 2001-2003 | |
| 81 | Joe Kennedy# | 531.0 | 2001-2003 | |
| 81 | Gil Meche# | 531.0 | 1999-2003 | |
| 83 | Jason Jennings# | 530.0 | 2001-2003 | |
| 84 | Josh Fogg# | 529.0 | 2001-2003 | |
| 85 | Jeff D'Amico# | 528.0 | 2001-2003 | |
| 86 | Chris Carpenter# | 525.0 | 2001-2003 | |
| 87 | Mike Hampton# | 522.0 | 2001-2003 | |
| 88 | Carl Pavano# | 521.0 | 2001-2003 | |
| 89 | Kevin Tapani# | 520.0 | 2001-2003 | |
| 90 | Jake Westbrook# | 518.0 | 2001-2003 | |
| 91 | Sean Douglass# | 517.0 | 2001-2003 | |
| 92 | Livan Hernandez# | 515.0 | 2001-2003 | |
| 93 | Brian Moehler# | 514.0 | 2001-2003 | |
| 94 | Bob Scanlan | 510.0 | 1991-2000 | |
| 95 | Jeff Fassero# | 508.0 | 2001-2003 | |
| 96 | Victor Zambrano# | 495.0 | 2001-2003 | |
| 97 | Jason Bere# | 492.0 | 2001-2003 | |
| 97 | Ismael Valdez# | 492.0 | 2001-2003 | |
| 99 | Ted Lilly# | 491.0 | 2001-2003 | |
| 100 | David Wells# | 484.0 | 2001-2003 |
