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| League History Index | Players | Teams | Managers | Leagues | Leaderboards | Awards | Accomplishments |
| Rank | Player | HR | YEAR | Open Season Leaderboard |
|---|---|---|---|---|
| 1 | Ángel Baca | 257 | 2009-2021 | |
| 2 | Rafael Campos | 175 | 2021-2028 | |
| 3 | Júlio Sánchez | 155 | 2006-2021 | |
| 4 | Chad Lewis | 139 | 2002-2016 | |
| 5 | Michael Little | 132 | 2009-2018 | |
| 6 | Nelson Cruz | 117 | 2007-2015 | |
| 6 | Brandon Martin | 117 | 2006-2019 | |
| 8 | Jason Dubois | 115 | 2005-2013 | |
| 9 | Bob Williams | 113 | 2018-2022 | |
| 10 | Trevor Stenissen# | 112 | 2024-2031 | |
| 11 | Curt Rice | 109 | 2019-2024 | |
| 12 | Dave Cannon | 106 | 2010-2022 | |
| 13 | Jack Rhodes | 104 | 2007-2015 | |
| 14 | Hunter Nolan | 101 | 2011-2014 | |
| 15 | Kurt Spencer | 99 | 2015-2020 | |
| 16 | Eugene Albert# | 97 | 2023-2029 | |
| 16 | Héctor Otero | 97 | 2018-2020 | |
| 18 | Zack Sims | 96 | 2019-2025 | |
| 19 | Rick Rollins | 93 | 2010-2014 | |
| 20 | Kenny Snyder# | 92 | 2023-2027 | |
| 21 | Jonathan Bryant | 91 | 2018-2024 | |
| 21 | Nelson Domínguez | 91 | 2016-2017 | |
| 21 | Anthony Rizzo | 91 | 2012-2021 | |
| 24 | Eric Black# | 90 | 2022-2030 | |
| 25 | Ángel González | 89 | 2010-2013 | |
| 25 | Owen Spring | 89 | 2011-2014 | |
| 25 | John Wells | 89 | 2016-2019 | |
| 28 | Felipe Costa# | 88 | 2026-2030 | |
| 28 | Balduin Thodberg | 88 | 2008-2015 | |
| 30 | Raúl Ortíz | 87 | 2015-2020 | |
| 30 | Tommy Wynn | 87 | 2012-2016 | |
| 32 | Danny Buckley | 85 | 2010-2018 | |
| 32 | Mike Foster | 85 | 2013-2017 | |
| 34 | Adam Biga# | 84 | 2026-2031 | |
| 35 | Doug Cramer | 83 | 2000-2005 | |
| 35 | Kent Ferris | 83 | 2008-2017 | |
| 35 | Steve Smith | 83 | 2012-2017 | |
| 38 | Richard Hall# | 82 | 2021-2023 | |
| 38 | Cedric Wilson | 82 | 2012-2019 | |
| 40 | Nick Beauregard | 80 | 2014-2015 | |
| 41 | Neal Thompson | 79 | 2012-2013 | |
| 42 | Matt Olson# | 78 | 2022-2024 | |
| 43 | Armando Cortés# | 77 | 2029-2031 | |
| 43 | Salvador Cruz# | 77 | 2025-2029 | |
| 43 | Kevin Davis | 77 | 2015-2018 | |
| 43 | Mitchell Gibson | 77 | 2012-2022 | |
| 43 | Nolan Huggahilli# | 77 | 2022-2028 | |
| 48 | John O'Reilly | 76 | 2010-2016 | |
| 49 | Howard Johnson | 75 | 2016-2018 | |
| 49 | Nigel Mchugh# | 75 | 2025-2031 | |
| 49 | Brad Shaw# | 75 | 2025-2031 | |
| 52 | Gianni Abeele# | 74 | 2029-2031 | |
| 52 | Shawn Alexander | 74 | 2006-2013 | |
| 52 | Norman Ambrose# | 74 | 2026-2031 | |
| 52 | Billy Butler | 74 | 2007-2015 | |
| 52 | Gabriel Sandoval# | 74 | 2027-2029 | |
| 57 | Bryan Christensen# | 73 | 2021-2028 | |
| 57 | Greg Pirkl | 73 | 1994-2004 | |
| 59 | Carlos Barbosa | 71 | 2018-2023 | |
| 59 | Nick Brooks# | 71 | 2027-2031 | |
| 59 | José González# | 71 | 2021-2022 | |
| 59 | Kyung-bae Kang# | 71 | 2024-2030 | |
| 59 | Alexander Robinson | 71 | 2018-2019 | |
| 59 | Joe Tanner | 71 | 2020-2022 | |
| 65 | Tim Fullerton | 70 | 2022-2025 | |
| 65 | Santiago Ibarra | 70 | 2018-2019 | |
| 65 | Slavomir Kajer# | 70 | 2016-2017 | |
| 65 | Claude Major# | 70 | 2021-2027 | |
| 65 | Juan Montoya# | 70 | 2022-2022 | |
| 65 | Dan Robinson | 70 | 2007-2016 | |
| 71 | Robinson Flores# | 69 | 2023-2029 | |
| 71 | Ben Gregory | 69 | 2018-2021 | |
| 71 | Mototsune Iitsuka# | 69 | 2030-2031 | |
| 71 | Luis Pérez | 69 | 2010-2023 | |
| 75 | R.J. James# | 68 | 2024-2029 | |
| 75 | Gary Leonard | 68 | 2018-2019 | |
| 75 | Rodrigo Medina# | 68 | 2030-2031 | |
| 75 | Jim Raynor# | 68 | 2027-2030 | |
| 75 | Troy Simon | 68 | 2020-2021 | |
| 75 | Dave Staton | 68 | 1993-2001 | |
| 81 | Rodger Bradley | 67 | 2020-2024 | |
| 81 | Conan Howe# | 67 | 2023-2025 | |
| 81 | Nick Markakis | 67 | 2007-2012 | |
| 84 | Todd Guerin | 66 | 2008-2014 | |
| 85 | Kris Bryant | 65 | 2020-2024 | |
| 85 | John Hampton | 65 | 2014-2018 | |
| 85 | Frank Miller# | 65 | 2024-2029 | |
| 85 | Tom Parkinson# | 65 | 2020-2020 | |
| 85 | Jim Stanley | 65 | 2022-2025 | |
| 85 | Tommy Trowsdale# | 65 | 2029-2031 | |
| 91 | Kevin Barnard | 64 | 2018-2020 | |
| 91 | Elmer Brown | 64 | 2019-2020 | |
| 91 | Ambrose Corona | 64 | 2016-2023 | |
| 91 | Toby David# | 64 | 2026-2028 | |
| 91 | Alberto Ledesma# | 64 | 2030-2031 | |
| 91 | Jack Lund | 64 | 2019-2021 | |
| 91 | Ron Perry | 64 | 2013-2013 | |
| 98 | Sancho Gallegos# | 63 | 2027-2028 | |
| 98 | Josh MacCloy# | 63 | 2021-2026 | |
| 98 | Ken Ross# | 63 | 2023-2025 |
