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| League History Index | Players | Teams | Managers | Leagues | Leaderboards | Awards | Accomplishments |
| Player | From-To | Avg | HR | RBI | W | L | SV | ERA | K |
|---|---|---|---|---|---|---|---|---|---|
| Troy O'Leary | 2001-2001 | .190 | 7 | 23 | 0 | 0 | 0 | 0.00 | 0 |
| Paul O'Neill | 2001-2001 | .250 | 13 | 77 | 0 | 0 | 0 | 0.00 | 0 |
| Sherman Obando | 1993-1997 | .239 | 13 | 49 | 0 | 0 | 0 | 0.00 | 0 |
| Alex Ochoa | 2001-2003 | .284 | 30 | 160 | 0 | 0 | 0 | 0.00 | 0 |
| Jose Offerman | 2001-2002 | .232 | 2 | 28 | 0 | 0 | 0 | 0.00 | 0 |
| Tomo Ohka | 2001-2003 | .182 | 0 | 0 | 18 | 11 | 4 | 5.26 | 109 |
| Will Ohman | 2001-2003 | .000 | 0 | 0 | 10 | 6 | 2 | 4.07 | 80 |
| Augie Ojeda | 2002-2003 | .157 | 0 | 5 | 0 | 0 | 0 | 0.00 | 0 |
| Miguel Ojeda | 2001-2001 | .197 | 1 | 5 | 0 | 0 | 0 | 0.00 | 0 |
| Jesus Olague | 2002-2003 | .286 | 0 | 0 | 1 | 1 | 0 | 2.70 | 19 |
| John Olerud | 2001-2003 | .269 | 43 | 213 | 0 | 0 | 0 | 0.00 | 0 |
| Omar Olivares | 2001-2001 | .222 | 1 | 1 | 2 | 1 | 2 | 3.69 | 39 |
| Darren Oliver | 2001-2003 | .117 | 0 | 3 | 9 | 19 | 1 | 6.43 | 153 |
| Joe Oliver | 2001-2002 | .160 | 1 | 5 | 0 | 0 | 0 | 0.00 | 0 |
| Kevin Olsen | 2001-2003 | .000 | 0 | 0 | 4 | 1 | 4 | 3.52 | 21 |
| Magglio Ordonez | 2001-2003 | .295 | 98 | 297 | 0 | 0 | 0 | 0.00 | 0 |
| Rey Ordonez | 2001-2002 | .215 | 0 | 31 | 0 | 0 | 0 | 0.00 | 0 |
| Jesse Orosco | 2001-2002 | .222 | 0 | 2 | 7 | 8 | 0 | 3.88 | 117 |
| David Ortiz | 2001-2003 | .222 | 11 | 33 | 0 | 0 | 0 | 0.00 | 0 |
| Hector Ortiz | 2001-2002 | .273 | 0 | 1 | 0 | 0 | 0 | 0.00 | 0 |
| Jose Ortiz | 2002-2003 | .250 | 2 | 5 | 0 | 0 | 0 | 0.00 | 0 |
| Ramon Ortiz | 2001-2003 | .145 | 1 | 7 | 20 | 21 | 0 | 4.07 | 254 |
| Russ Ortiz | 2001-2003 | .164 | 4 | 13 | 43 | 31 | 0 | 3.71 | 440 |
| Donovan Osborne | 1992-2002 | .165 | 1 | 19 | 49 | 46 | 0 | 3.99 | 559 |
| Keith Osik | 2001-2001 | .000 | 0 | 0 | 0 | 0 | 0 | 0.00 | 0 |
| Antonio Osuna | 2001-2003 | .000 | 0 | 0 | 21 | 16 | 4 | 4.65 | 209 |
| Roy Oswalt | 2001-2003 | .193 | 2 | 21 | 52 | 20 | 0 | 3.63 | 641 |
| Ricky Otero | 1995-1997 | .256 | 2 | 36 | 0 | 0 | 0 | 0.00 | 0 |
| Eric Owens | 2001-2002 | .405 | 1 | 8 | 0 | 0 | 0 | 0.00 | 0 |
| Pablo Ozuna | 2000-2000 | .333 | 0 | 0 | 0 | 0 | 0 | 0.00 | 0 |
| Player | From-To | Avg | HR | RBI | W | L | SV | ERA | K |
