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| League History Index | Players | Teams | Managers | Leagues | Leaderboards | Awards | Accomplishments |
| Rank | Player | H | YEAR | Open Career Leaderboard |
|---|---|---|---|---|
| 1 | David Bush | 293 | 2011 | |
| 2 | Brandon Webb* | 279 | 2014 | |
| 3 | Roger Clemens* | 275 | 1989 | |
| 4 | Bill Moore# | 271 | 2026 | |
| 5 | Brett Myers | 266 | 2017 | |
| 6 | Steve Karsay | 265 | 2000 | |
| 7 | Aaron Sele* | 262 | 2004 | |
| 8 | Bronson Arroyo | 261 | 2011 | |
| 8 | Manny Aybar | 261 | 2000 | |
| 10 | George Burke# | 260 | 2021 | |
| 11 | Nolan Arnold | 259 | 2022 | |
| 11 | Brandon Duckworth | 259 | 2011 | |
| 13 | Andy Ashby | 258 | 2000 | |
| 14 | Kumar Rocker# | 256 | 2025 | |
| 14 | Carlos Perez | 256 | 1997 | |
| 14 | Chris Holt | 256 | 1998 | |
| 17 | Bartolo Colon | 255 | 2002 | |
| 18 | Jose Berrios# | 254 | 2030 | |
| 19 | Dylan Scott | 253 | 2011 | |
| 19 | Emílio Rosas# | 253 | 2028 | |
| 19 | Kyle Sackett | 253 | 2014 | |
| 19 | Shane Bieber# | 253 | 2028 | |
| 19 | Tim Pulliam# | 253 | 2027 | |
| 19 | Brad Radke | 253 | 1996 | |
| 25 | David Brewster | 252 | 2027 | |
| 25 | Ben Parks# | 252 | 2028 | |
| 25 | Ted Johnson# | 252 | 2026 | |
| 28 | Carlos Perez | 251 | 1996 | |
| 28 | Brandon Webb* | 251 | 2020 | |
| 28 | Alan Benes | 251 | 2001 | |
| 28 | Jack Lawrence# | 251 | 2027 | |
| 28 | Félix Zamora | 251 | 2014 | |
| 28 | Hipolito Pichardo | 251 | 1995 | |
| 28 | Eric Ford# | 251 | 2026 | |
| 35 | George Burke# | 250 | 2024 | |
| 35 | John Smoltz | 250 | 1988 | |
| 35 | Rheal Cormier | 250 | 1996 | |
| 35 | Rheal Cormier | 250 | 1999 | |
| 35 | Randy Tomlin | 250 | 1991 | |
| 35 | Brett Myers | 250 | 2012 | |
| 41 | Richard Verhoeve# | 249 | 2030 | |
| 41 | Emílio Aguilar | 249 | 2014 | |
| 41 | Randy Tomlin | 249 | 1992 | |
| 44 | Roy Ward | 248 | 2024 | |
| 44 | Stephen Strasburg | 248 | 2016 | |
| 44 | Tim Worrell | 248 | 1995 | |
| 44 | Senichi Tanaka# | 248 | 2030 | |
| 44 | Rheal Cormier | 248 | 1991 | |
| 44 | Hipolito Pichardo | 248 | 1999 | |
| 44 | Carlos Perez | 248 | 1999 | |
| 51 | Carlos Perez | 247 | 1998 | |
| 51 | Alan Benes | 247 | 2000 | |
| 53 | Jesús Martínez# | 246 | 2029 | |
| 53 | Jimmy Anderson | 246 | 2008 | |
| 53 | Chris Holt | 246 | 2001 | |
| 53 | Dillon Gee | 246 | 2016 | |
| 53 | Emílio Aguilar | 246 | 2017 | |
| 53 | Josh Brown | 246 | 2014 | |
| 59 | Robert Dixon# | 245 | 2027 | |
| 59 | Brian Tollberg | 245 | 2000 | |
| 59 | Rheal Cormier | 245 | 1998 | |
| 59 | Ben Parks# | 245 | 2026 | |
| 63 | Josh Beckett* | 244 | 2015 | |
| 63 | Steve Karsay | 244 | 1994 | |
| 63 | Roy Oswalt* | 244 | 2010 | |
| 63 | John Smoltz | 244 | 1994 | |
| 63 | Brian Moehler | 244 | 1998 | |
| 63 | Brandon Duckworth | 244 | 2010 | |
| 63 | Mark Buehrle | 244 | 2012 | |
| 63 | Hipolito Pichardo | 244 | 2008 | |
| 71 | Emílio Aguilar | 243 | 2015 | |
| 71 | Tom Glavine | 243 | 1987 | |
| 71 | Ben Parks# | 243 | 2027 | |
| 71 | Madison Bumgarner | 243 | 2021 | |
| 71 | Rheal Cormier | 243 | 1997 | |
| 71 | John Smoltz | 243 | 1989 | |
| 71 | Michael Brusse# | 243 | 2029 | |
| 71 | Bruce Byrd | 243 | 2014 | |
| 79 | Mitsunari Yoshida# | 242 | 2029 | |
| 79 | Dillon Gee | 242 | 2017 | |
| 79 | Julián Martínez | 242 | 2014 | |
| 79 | Austin Braden | 242 | 2015 | |
| 79 | Chris Holt | 242 | 2000 | |
| 79 | Dylan Scott | 242 | 2010 | |
| 79 | Chris Campbell | 242 | 2025 | |
| 79 | Bill Mann | 242 | 2015 | |
| 79 | Brett Myers | 242 | 2014 | |
| 88 | Simon Duncombe | 240 | 2010 | |
| 88 | Steve Nebraska | 240 | 2017 | |
| 88 | Reece MacKinley | 240 | 2014 | |
| 88 | Jeff Francis | 240 | 2013 | |
| 88 | Emílio García | 240 | 2017 | |
| 88 | Reece MacKinley | 240 | 2018 | |
| 94 | John Smoltz | 239 | 1990 | |
| 94 | Carl Pavano | 239 | 2009 | |
| 94 | Randy Tomlin | 239 | 1990 | |
| 94 | Brian Dalton | 239 | 2014 | |
| 94 | Jimmy Anderson | 239 | 2005 | |
| 94 | Albert López | 239 | 2006 | |
| 94 | Mike King# | 239 | 2028 |
