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| League History Index | Players | Teams | Managers | Leagues | Leaderboards | Awards | Accomplishments |
| Rank | Player | OAVG | YEAR | Open Postseason Leaderboard |
|---|---|---|---|---|
| 1 | Brad Cochran | .1667 | 2019-2027 | |
| 1 | Gilberto Martínez# | .1667 | 2025-2031 | |
| 3 | Roger Bailey | .1677 | 2003-2014 | |
| 4 | John Wood# | .1696 | 2029-2031 | |
| 5 | Dan Woods# | .1753 | 2023-2031 | |
| 6 | Chad Qualls | .1795 | 2006-2020 | |
| 7 | Luis Anguiana# | .1802 | 2026-2031 | |
| 8 | Joel Zumaya | .1803 | 2011-2023 | |
| 9 | David Price | .1854 | 2011-2019 | |
| 10 | Alfredo Gómez# | .1862 | 2028-2031 | |
| 11 | Bob Schultz | .1875 | 2013-2022 | |
| 12 | Matt J Miller | .1878 | 2003-2016 | |
| 13 | Paul Hale# | .1880 | 2020-2031 | |
| 14 | Dan White | .1915 | 2012-2021 | |
| 15 | Heath Bell | .1967 | 2004-2021 | |
| 16 | Clifton Jackson# | .1989 | 2024-2029 | |
| 17 | Ignacio Reyes# | .2014 | 2028-2031 | |
| 18 | Francisco Ramírez# | .2025 | 2017-2030 | |
| 19 | Jonathan Papelbon | .2031 | 2008-2021 | |
| 20 | António Ortíz | .2033 | 2002-2011 | |
| 21 | Randy D Johnson | .2066 | 1988-2003 | |
| 22 | Ugueth Urbina | .2067 | 1995-2013 | |
| 23 | Duane Wilson | .2069 | 2008-2020 | |
| 24 | Bryan Kent# | .2086 | 2025-2031 | |
| 25 | Ian Kennedy | .2092 | 2010-2019 | |
| 26 | Ronald Moyer# | .2101 | 2023-2031 | |
| 27 | Javier Vazquez* | .2120 | 1998-2013 | |
| 28 | Brett Tomko | .2132 | 1997-2004 | |
| 29 | Roger Clemens* | .2137 | 1984-2006 | |
| 30 | Daron Maddox | .2152 | 2015-2027 | |
| 31 | A J Burnett | .2164 | 1999-2010 | |
| 31 | Eric Hurley | .2164 | 2007-2020 | |
| 33 | Ryan Arnold | .2184 | 2012-2021 | |
| 34 | Henry Moss# | .2185 | 2019-2029 | |
| 35 | Adrian Ackermann | .2188 | 2014-2022 | |
| 36 | Josh Fogg | .2190 | 2001-2012 | |
| 37 | Jason Ellis | .2192 | 2013-2027 | |
| 38 | Santiago Herrera | .2200 | 2000-2018 | |
| 38 | Thomas Rice# | .2200 | 2017-2031 | |
| 38 | Eduardo Vázquez# | .2200 | 2023-2030 | |
| 41 | Joakim Soria | .2205 | 2012-2022 | |
| 42 | Malcolm Zegwaard | .2206 | 2013-2020 | |
| 43 | Amdre Nova# | .2207 | 2030-2031 | |
| 44 | Allen Bailey | .2210 | 2011-2023 | |
| 45 | Carlos Jiménez# | .2213 | 2021-2031 | |
| 46 | Eddie Morgan* | .2215 | 2005-2019 | |
| 47 | Raúl López | .2222 | 2000-2016 | |
| 48 | Charlie Frohwirth | .2227 | 2012-2024 | |
| 49 | Jeff Samardzija | .2230 | 2009-2021 | |
| 50 | Tim Spooneybarger | .2231 | 2001-2017 | |
| 50 | Jason Dickson | .2231 | 1997-2006 | |
| 52 | Chris Sharp# | .2245 | 2021-2031 | |
| 53 | Adelphos Papademetriou | .2254 | 2002-2011 | |
| 54 | Chuck Smith | .2261 | 2000-2009 | |
| 55 | Archie Esparza# | .2268 | 2025-2031 | |
| 56 | Hipolito Pichardo | .2270 | 1992-2008 | |
| 56 | Tim Pulliam# | .2270 | 2026-2031 | |
| 58 | Kevin Walters | .2277 | 2003-2015 | |
| 59 | Scott Sanders | .2278 | 1993-2007 | |
| 60 | Ken Brandon | .2281 | 2019-2029 | |
| 61 | Scott Randall | .2292 | 2003-2020 | |
| 62 | James Ryan# | .2294 | 2017-2027 | |
| 63 | Daniel Patterson | .2295 | 2017-2029 | |
| 64 | Dennis Redden# | .2296 | 2029-2031 | |
| 64 | Mark Prior* | .2296 | 2002-2016 | |
| 66 | Manny Aybar | .2299 | 1997-2008 | |
| 67 | Felix Hernandez | .2302 | 2009-2020 | |
| 67 | Barry Zito | .2302 | 2000-2014 | |
| 69 | Héctor Bernal# | .2314 | 2024-2031 | |
| 70 | Jerry Patterson | .2316 | 2002-2015 | |
| 70 | Kumar Rocker# | .2316 | 2020-2026 | |
| 72 | Gabe Johnson | .2328 | 2019-2028 | |
| 72 | Steve Karsay | .2328 | 1993-2007 | |
| 74 | Jose A Nunez | .2331 | 2001-2012 | |
| 75 | John Christensen | .2336 | 2015-2024 | |
| 76 | Carlos Cotter | .2338 | 2008-2020 | |
| 77 | Justin Thompson | .2344 | 2016-2026 | |
| 78 | Erik Bedard | .2346 | 2004-2013 | |
| 79 | Jake Peavy | .2348 | 2002-2017 | |
| 80 | Anderson Fergerson | .2353 | 2014-2028 | |
| 81 | Tito Smith# | .2359 | 2020-2031 | |
| 82 | Johan Santana | .2364 | 2000-2015 | |
| 83 | Eldon Hernández | .2368 | 2018-2026 | |
| 84 | Máximo Sánchez | .2371 | 2015-2025 | |
| 85 | Guillermo Mota | .2381 | 1999-2010 | |
| 86 | Toki Nagai | .2384 | 2004-2015 | |
| 87 | Kevin Gregg | .2388 | 2004-2017 | |
| 88 | Jorge Enríquez# | .2397 | 2020-2031 | |
| 89 | Felipe Herrera# | .2400 | 2021-2031 | |
| 90 | Micah Olson# | .2406 | 2016-2031 | |
| 91 | Matt Morris | .2407 | 1997-2005 | |
| 92 | Cole Hamels* | .2411 | 2007-2023 | |
| 93 | Esteban Loaiza | .2414 | 1995-2006 | |
| 94 | Bob Jenkins* | .2421 | 2008-2023 | |
| 95 | Raúl Mateo# | .2426 | 2026-2031 | |
| 96 | José Torres# | .2427 | 2026-2031 | |
| 97 | Nolan Arnold | .2429 | 2011-2022 | |
| 98 | CC Sabathia* | .2431 | 2001-2019 | |
| 99 | David Stevens | .2434 | 2019-2030 | |
| 100 | Chad Billingsley | .2441 | 2008-2024 |
