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| League History Index | Players | Teams | Managers | Leagues | Leaderboards | Awards | Accomplishments |
| Rank | Player | K9 | YEAR | Open Postseason Leaderboard |
|---|---|---|---|---|
| 1 | Gilberto Martínez# | 16.46 | 2025-2031 | |
| 2 | Ignacio Reyes# | 14.56 | 2028-2031 | |
| 3 | Dellin Betances | 13.50 | 2012-2028 | |
| 4 | Jonathan Papelbon | 12.86 | 2008-2021 | |
| 5 | Chris Sharp# | 12.53 | 2021-2031 | |
| 6 | Archie Esparza# | 12.31 | 2025-2031 | |
| 7 | Nathan Whalebelly | 12.06 | 2015-2029 | |
| 8 | Ugueth Urbina | 12.04 | 1995-2013 | |
| 9 | Rafael Soriano | 12.03 | 2002-2013 | |
| 10 | John Wood# | 11.97 | 2029-2031 | |
| 11 | Paul Hale# | 11.65 | 2020-2031 | |
| 12 | Dan White | 11.54 | 2012-2021 | |
| 13 | Jim Berthe# | 11.32 | 2025-2031 | |
| 14 | James Ryan# | 11.09 | 2017-2027 | |
| 15 | Bob Schultz | 11.08 | 2013-2022 | |
| 16 | Ronald Moyer# | 11.07 | 2023-2031 | |
| 17 | Ed Anderson | 10.97 | 2018-2030 | |
| 18 | Brad Cochran | 10.90 | 2019-2027 | |
| 19 | Randy D Johnson | 10.74 | 1988-2003 | |
| 20 | Brian Wilson | 10.61 | 2007-2021 | |
| 21 | Jake McGee | 10.57 | 2015-2023 | |
| 22 | Malcolm Zegwaard | 10.37 | 2013-2020 | |
| 23 | Gabe Johnson | 10.20 | 2019-2028 | |
| 24 | Scott Kazmir | 10.11 | 2004-2019 | |
| 25 | José Torres# | 10.08 | 2026-2031 | |
| 26 | Mark Prior* | 9.95 | 2002-2016 | |
| 27 | Joel Zumaya | 9.92 | 2011-2023 | |
| 28 | Juan Velázquez# | 9.85 | 2025-2031 | |
| 29 | Wade Miller | 9.74 | 1999-2012 | |
| 30 | Byung-Hyun Kim | 9.68 | 1999-2014 | |
| 31 | Johan Santana | 9.67 | 2000-2015 | |
| 32 | Jose A Nunez | 9.59 | 2001-2012 | |
| 33 | Luis Vigil# | 9.54 | 2019-2027 | |
| 34 | Alfredo Huerta# | 9.53 | 2022-2030 | |
| 35 | George Williams# | 9.50 | 2024-2031 | |
| 36 | Thomas Rice# | 9.49 | 2017-2031 | |
| 37 | Stephen Strasburg | 9.47 | 2011-2027 | |
| 38 | John Christensen | 9.40 | 2015-2024 | |
| 39 | Eldon Hernández | 9.38 | 2018-2026 | |
| 40 | Jason Dickson | 9.37 | 1997-2006 | |
| 41 | Leo Erickson# | 9.30 | 2022-2029 | |
| 42 | Heath Bell | 9.26 | 2004-2021 | |
| 43 | Roger Clemens* | 9.22 | 1984-2006 | |
| 44 | Matt J Miller | 9.17 | 2003-2016 | |
| 44 | Santiago Herrera | 9.17 | 2000-2018 | |
| 46 | Jeff Shoemaker# | 9.12 | 2025-2031 | |
| 47 | Bob Richardson# | 9.09 | 2027-2031 | |
| 48 | Bob Frazier# | 9.00 | 2019-2027 | |
| 48 | Leland Hart# | 9.00 | 2025-2031 | |
| 50 | Dan Wilkerson# | 8.96 | 2023-2031 | |
| 51 | José Pérez | 8.92 | 2011-2022 | |
| 52 | Bob Jenkins* | 8.85 | 2008-2023 | |
| 53 | Avery Webb# | 8.84 | 2018-2025 | |
| 54 | Roberto Sánchez# | 8.81 | 2027-2031 | |
| 55 | Raimondo Amberezzio# | 8.80 | 2026-2031 | |
| 56 | Austin Willis | 8.76 | 2018-2027 | |
| 57 | Dan Woods# | 8.73 | 2023-2031 | |
| 57 | Carlos Jiménez# | 8.73 | 2021-2031 | |
| 59 | Máximo Sánchez | 8.72 | 2015-2025 | |
| 60 | Scott Sanders | 8.70 | 1993-2007 | |
| 61 | Shelby Miller | 8.69 | 2016-2027 | |
| 61 | Kumar Rocker# | 8.69 | 2020-2026 | |
| 63 | Javier Vazquez* | 8.68 | 1998-2013 | |
| 64 | Anderson Fergerson | 8.66 | 2014-2028 | |
| 64 | Bryan Kent# | 8.66 | 2025-2031 | |
| 64 | Dwight Tucker | 8.66 | 2011-2027 | |
| 67 | George Sherrill | 8.49 | 2005-2021 | |
| 68 | Daron Maddox | 8.48 | 2015-2027 | |
| 69 | Cisco Castellanos# | 8.47 | 2025-2031 | |
| 70 | Rod Beck | 8.44 | 1991-2004 | |
| 71 | Roger Bailey | 8.43 | 2003-2014 | |
| 72 | Doug Jones | 8.41 | 2012-2024 | |
| 73 | Eduard Fotachi# | 8.39 | 2019-2031 | |
| 74 | Carlos Durán# | 8.36 | 2028-2031 | |
| 75 | Chuck Smith | 8.33 | 2000-2009 | |
| 76 | Jorge Enríquez# | 8.32 | 2020-2031 | |
| 77 | Steve Watts | 8.31 | 2008-2021 | |
| 78 | Henry Moss# | 8.27 | 2019-2029 | |
| 79 | Andre Ford | 8.26 | 2018-2023 | |
| 80 | Carlos Zambrano | 8.25 | 2001-2019 | |
| 81 | Josh Beckett* | 8.22 | 2001-2020 | |
| 81 | Julián Martínez | 8.22 | 2007-2019 | |
| 83 | António Ortíz | 8.21 | 2002-2011 | |
| 83 | Ben Sheets | 8.21 | 2001-2015 | |
| 85 | Micah Olson# | 8.15 | 2016-2031 | |
| 85 | Nolan Arnold | 8.15 | 2011-2022 | |
| 85 | Robert Dixon# | 8.15 | 2019-2031 | |
| 88 | Raúl Aguilar# | 8.14 | 2020-2031 | |
| 88 | Gerrit Cole# | 8.14 | 2022-2031 | |
| 90 | Kevin Gregg | 8.13 | 2004-2017 | |
| 90 | Yong-hun Yi# | 8.13 | 2027-2031 | |
| 92 | Kelvim Escobar | 8.12 | 1997-2018 | |
| 92 | Jeffery McGhee# | 8.12 | 2018-2026 | |
| 92 | Steve Karsay | 8.12 | 1993-2007 | |
| 92 | Angel Miranda | 8.12 | 1993-2006 | |
| 96 | Felix Hernandez | 8.02 | 2009-2020 | |
| 97 | Allen Bailey | 8.00 | 2011-2023 | |
| 98 | Miguel Moreno# | 7.99 | 2020-2031 | |
| 99 | Kyle Jones | 7.94 | 2016-2025 | |
| 100 | Manuel Vázquez# | 7.86 | 2024-2031 |
