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| League History Index | Players | Teams | Managers | Leagues | Leaderboards | Awards | Accomplishments |
| Rank | Player | IP | YEAR | Open Postseason Leaderboard |
|---|---|---|---|---|
| 1 | Lee Myers# | 271.0 | 2019-2031 | |
| 2 | Bob Jenkins* | 260.0 | 2008-2023 | |
| 3 | Roger Clemens* | 249.0 | 1984-2006 | |
| 4 | George Connolly# | 248.0 | 2018-2031 | |
| 5 | Joba Chamberlain | 233.0 | 2012-2027 | |
| 6 | Madison Bumgarner | 228.0 | 2014-2031 | |
| 7 | Zack Greinke* | 226.0 | 2005-2020 | |
| 8 | Brandon Webb* | 201.0 | 2004-2024 | |
| 9 | Tim Lincecum | 183.0 | 2009-2025 | |
| 10 | Javier Vazquez* | 180.0 | 1998-2013 | |
| 11 | CC Sabathia* | 176.0 | 2001-2019 | |
| 12 | Roy Oswalt* | 174.0 | 2001-2016 | |
| 13 | Allen Bailey | 168.0 | 2011-2023 | |
| 14 | Anthony Hunt | 167.0 | 2016-2028 | |
| 15 | Eddie Morgan* | 159.0 | 2005-2019 | |
| 16 | Aaron Sele* | 150.0 | 1993-2006 | |
| 17 | Jason Ellis | 149.0 | 2013-2027 | |
| 18 | Chad Billingsley | 146.0 | 2008-2024 | |
| 19 | Major Pixel | 145.0 | 2007-2021 | |
| 20 | Reece MacKinley | 138.0 | 2007-2024 | |
| 21 | Gary Lefebvre | 137.0 | 2002-2016 | |
| 22 | Kevin Schaefer | 133.0 | 2012-2023 | |
| 23 | Noah Lowry | 132.0 | 2004-2015 | |
| 24 | Jon Lieber | 131.0 | 1994-2009 | |
| 25 | Cole Hamels* | 128.0 | 2007-2023 | |
| 25 | Kevin Walters | 128.0 | 2003-2015 | |
| 27 | José Torres# | 127.0 | 2026-2031 | |
| 28 | Chip Blake# | 125.0 | 2022-2030 | |
| 29 | Dwight Tucker | 123.0 | 2011-2027 | |
| 29 | Andy Ashby | 123.0 | 1991-2002 | |
| 31 | John Halama | 117.0 | 1998-2008 | |
| 32 | Jeff Samardzija | 114.0 | 2009-2021 | |
| 32 | Roy Ward | 114.0 | 2014-2026 | |
| 34 | Archie Esparza# | 113.0 | 2025-2031 | |
| 35 | Jose Acevedo | 111.0 | 2002-2013 | |
| 35 | R A Dickey | 111.0 | 2002-2018 | |
| 35 | Roy Halladay* | 111.0 | 1998-2014 | |
| 38 | Carlos Cotter | 110.0 | 2008-2020 | |
| 39 | Tim Pulliam# | 105.0 | 2026-2031 | |
| 40 | Raimondo Amberezzio# | 103.0 | 2026-2031 | |
| 40 | Tommy Austin | 103.0 | 2014-2023 | |
| 40 | Jerry Patterson | 103.0 | 2002-2015 | |
| 43 | Dan Woods# | 100.0 | 2023-2031 | |
| 44 | Tito Smith# | 98.0 | 2020-2031 | |
| 44 | Mark Mulder | 98.0 | 2000-2015 | |
| 44 | Randy D Johnson | 98.0 | 1988-2003 | |
| 44 | John Smoltz | 98.0 | 1988-2003 | |
| 48 | Gerrit Cole# | 97.0 | 2022-2031 | |
| 49 | Stephen Strasburg | 96.0 | 2011-2027 | |
| 50 | Jake Peavy | 93.0 | 2002-2017 | |
| 51 | Daniel Patterson | 92.0 | 2017-2029 | |
| 52 | James Ryan# | 91.0 | 2017-2027 | |
| 53 | Jimmy Anderson | 90.0 | 1999-2011 | |
| 54 | Jerry Burrell# | 89.0 | 2016-2031 | |
| 55 | Eduard Fotachi# | 88.0 | 2019-2031 | |
| 55 | Shelby Miller | 88.0 | 2016-2027 | |
| 57 | Keith McCoy# | 87.0 | 2020-2031 | |
| 58 | Howard Littlewood# | 86.0 | 2020-2031 | |
| 58 | Scott Kazmir | 86.0 | 2004-2019 | |
| 58 | Daron Maddox | 86.0 | 2015-2027 | |
| 61 | Alfredo Huerta# | 85.0 | 2022-2030 | |
| 62 | Miguel Moreno# | 83.0 | 2020-2031 | |
| 63 | Ian Richardson | 82.0 | 2009-2019 | |
| 63 | Steve Karsay | 82.0 | 1993-2007 | |
| 65 | David Stevens | 81.0 | 2019-2030 | |
| 65 | Juan Velázquez# | 81.0 | 2025-2031 | |
| 67 | Fred Hawkins | 80.0 | 2019-2028 | |
| 68 | Toki Nagai | 79.0 | 2004-2015 | |
| 69 | Garth Vaughn | 78.0 | 2008-2020 | |
| 69 | Bud Smith | 78.0 | 2001-2014 | |
| 69 | Jeff Shoemaker# | 78.0 | 2025-2031 | |
| 72 | John Fletcher# | 76.0 | 2026-2031 | |
| 73 | Austin Willis | 75.0 | 2018-2027 | |
| 74 | Brian Wilson | 74.0 | 2007-2021 | |
| 74 | Eric Hurley | 74.0 | 2007-2020 | |
| 76 | Matt Cain | 73.0 | 2007-2020 | |
| 76 | Kyle Jones | 73.0 | 2016-2025 | |
| 78 | Rich Burton | 71.0 | 2018-2030 | |
| 78 | Jesse Hayes# | 71.0 | 2019-2026 | |
| 78 | Ken Brandon | 71.0 | 2019-2029 | |
| 81 | Felix Hernandez | 70.0 | 2009-2020 | |
| 81 | Benny Howard# | 70.0 | 2021-2029 | |
| 81 | Carlos Durán# | 70.0 | 2028-2031 | |
| 84 | Scott Sanders | 69.0 | 1993-2007 | |
| 84 | Roger Powell | 69.0 | 2020-2028 | |
| 86 | Manuel Vázquez# | 68.0 | 2024-2031 | |
| 86 | Dennis Redden# | 68.0 | 2029-2031 | |
| 86 | Ismael Valdez* | 68.0 | 1994-2010 | |
| 86 | Dan Wilkerson# | 68.0 | 2023-2031 | |
| 86 | Heath Bell | 68.0 | 2004-2021 | |
| 91 | Nolan Arnold | 67.0 | 2011-2022 | |
| 91 | Diego Velázquez# | 67.0 | 2027-2031 | |
| 93 | William Pierce# | 66.0 | 2025-2031 | |
| 93 | Josh Fogg | 66.0 | 2001-2012 | |
| 93 | Sergio Guerrero# | 66.0 | 2023-2031 | |
| 93 | Paul Phelps | 66.0 | 2014-2026 | |
| 97 | Paul Hale# | 65.0 | 2020-2031 | |
| 97 | Jesús Bravo# | 65.0 | 2026-2031 | |
| 97 | John Lambert# | 65.0 | 2022-2031 | |
| 100 | Jeff Sawyer | 64.0 | 2006-2018 |
