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| League History Index | Players | Teams | Managers | Leagues | Leaderboards | Awards | Accomplishments |
| Rank | Player | SV | YEAR | Open Postseason Leaderboard |
|---|---|---|---|---|
| 1 | Wilford Chambers* | 26 | 2006-2025 | |
| 2 | Santiago Herrera | 21 | 2000-2018 | |
| 3 | Brad Cochran | 18 | 2019-2027 | |
| 3 | Chris Sharp# | 18 | 2021-2031 | |
| 5 | Eric DuBose | 16 | 2002-2015 | |
| 6 | Aquilino Lopez | 15 | 2005-2019 | |
| 7 | Jose Melendez | 14 | 1991-2005 | |
| 7 | Brian Wilson | 14 | 2007-2021 | |
| 9 | Heath Bell | 13 | 2004-2021 | |
| 9 | Jonathan Papelbon | 13 | 2008-2021 | |
| 11 | Joel Zumaya | 12 | 2011-2023 | |
| 12 | Jesús Enríquez | 11 | 2001-2015 | |
| 13 | Raúl Aguilar# | 10 | 2020-2031 | |
| 13 | Thomas Rice# | 10 | 2017-2031 | |
| 13 | Dan Woods# | 10 | 2023-2031 | |
| 16 | Dellin Betances | 9 | 2012-2028 | |
| 16 | Courtney Duncan | 9 | 2001-2010 | |
| 16 | Charlie Frohwirth | 9 | 2012-2024 | |
| 16 | Daron Maddox | 9 | 2015-2027 | |
| 16 | George Williams# | 9 | 2024-2031 | |
| 21 | Rod Beck | 8 | 1991-2004 | |
| 21 | José Daniels | 8 | 2019-2029 | |
| 21 | Felipe Herrera# | 8 | 2021-2031 | |
| 21 | Grant Roberts | 8 | 2000-2013 | |
| 21 | Dave Wells | 8 | 2002-2013 | |
| 26 | Jinrich Batkoka# | 7 | 2017-2031 | |
| 26 | Rafael Betancourt | 7 | 2004-2019 | |
| 26 | Kelvim Escobar | 7 | 1997-2018 | |
| 26 | Billy Koch | 7 | 1999-2010 | |
| 26 | Cory Lidle | 7 | 1997-2010 | |
| 26 | Shelby Miller | 7 | 2016-2027 | |
| 26 | Bill Moore# | 7 | 2020-2031 | |
| 26 | Andrew Murphy | 7 | 2014-2025 | |
| 26 | Ignacio Reyes# | 7 | 2028-2031 | |
| 26 | James Ryan# | 7 | 2017-2027 | |
| 26 | Mo Sanford | 7 | 1991-2005 | |
| 26 | Paul Shuey | 7 | 1996-2006 | |
| 38 | Jerry Burrell# | 6 | 2016-2031 | |
| 38 | Pedro Castro | 6 | 2012-2022 | |
| 38 | Jennie Finch | 6 | 2005-2020 | |
| 38 | Lúcio Gonzáles# | 6 | 2030-2031 | |
| 38 | Sergio Guerrero# | 6 | 2023-2031 | |
| 38 | Bryan Kent# | 6 | 2025-2031 | |
| 38 | Hilton Lewis | 6 | 2019-2025 | |
| 38 | Derek Lowe | 6 | 1997-2007 | |
| 38 | Sweetbreads Mayer | 6 | 2006-2021 | |
| 38 | Greg McMichael | 6 | 1993-2005 | |
| 38 | Daniel Patterson | 6 | 2017-2029 | |
| 38 | Chad Qualls | 6 | 2006-2020 | |
| 38 | Mariano Rivera | 6 | 1995-2006 | |
| 38 | Tom Scott | 6 | 2008-2020 | |
| 38 | Tito Smith# | 6 | 2020-2031 | |
| 38 | Rafael Soriano | 6 | 2002-2013 | |
| 38 | Steve White | 6 | 2016-2027 | |
| 55 | Gerrit Cole# | 5 | 2022-2031 | |
| 55 | Gerardo Domínguez# | 5 | 2029-2031 | |
| 55 | Joel Hanrahan | 5 | 2009-2021 | |
| 55 | Steve J Kline | 5 | 1997-2007 | |
| 55 | Scott MacRae | 5 | 2001-2009 | |
| 55 | Jerry Nelson | 5 | 2009-2017 | |
| 55 | Mac Suzuki | 5 | 2002-2008 | |
| 55 | John Wood# | 5 | 2029-2031 | |
| 55 | Cris Ávila# | 5 | 2026-2031 | |
| 64 | Doug Bochtler | 4 | 1996-2009 | |
| 64 | Tyler Clippard | 4 | 2009-2017 | |
| 64 | Chris Cook# | 4 | 2020-2028 | |
| 64 | Mike Crudale | 4 | 2002-2011 | |
| 64 | Jorge Enríquez# | 4 | 2020-2031 | |
| 64 | Edwin Johnson | 4 | 2018-2026 | |
| 64 | Craig Kimbrel | 4 | 2010-2025 | |
| 64 | Jake McGee | 4 | 2015-2023 | |
| 64 | Guillermo Mota | 4 | 1999-2010 | |
| 64 | Denny Neagle | 4 | 1991-2005 | |
| 64 | Juan Carlos Ortíz# | 4 | 2026-2030 | |
| 64 | Kevin Pryor | 4 | 2012-2023 | |
| 64 | Shane Reynolds | 4 | 1992-2005 | |
| 64 | Henry Rowengartner | 4 | 2004-2019 | |
| 64 | Carl Sadler | 4 | 2002-2011 | |
| 64 | Huston Street | 4 | 2008-2019 | |
| 64 | Iván Vargas# | 4 | 2024-2029 | |
| 64 | Terrell Wade | 4 | 1995-2010 | |
| 64 | Kojiro Yamada# | 4 | 2029-2031 | |
| 83 | Jim Berthe# | 3 | 2025-2031 | |
| 83 | Colin Beton# | 3 | 2021-2028 | |
| 83 | Ryan Carter | 3 | 2020-2025 | |
| 83 | Leo Erickson# | 3 | 2022-2029 | |
| 83 | Anderson Fergerson | 3 | 2014-2028 | |
| 83 | Patrick Gary | 3 | 2019-2027 | |
| 83 | Kevin Gregg | 3 | 2004-2017 | |
| 83 | Paul Hale# | 3 | 2020-2031 | |
| 83 | Mike Harkey | 3 | 1988-2004 | |
| 83 | Leland Hart# | 3 | 2025-2031 | |
| 83 | Steve Hernández | 3 | 2003-2013 | |
| 83 | Jeff Juden | 3 | 1991-2009 | |
| 83 | Duane Martin | 3 | 2009-2019 | |
| 83 | Paco Martínez | 3 | 2002-2011 | |
| 83 | Hannes Meissnitzer | 3 | 2016-2028 | |
| 83 | Matt J Miller | 3 | 2003-2016 | |
| 83 | William Miller# | 3 | 2024-2031 | |
| 83 | Héctor Montoya# | 3 | 2027-2031 |
