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| League History Index | Players | Teams | Managers | Leagues | Leaderboards | Awards | Accomplishments |
| Rank | Player | K9 | YEAR | Open Postseason Career Leaderboard |
|---|---|---|---|---|
| 1 | Ignacio Reyes# | 17.18 | 2028 | |
| 2 | Gilberto Martínez# | 16.46 | 2029 | |
| 3 | Ugueth Urbina | 16.09 | 1999 | |
| 4 | Paul Hale# | 13.95 | 2027 | |
| 5 | James Ryan# | 13.86 | 2022 | |
| 6 | John Wood# | 12.79 | 2029 | |
| 7 | Nathan Whalebelly | 12.46 | 2016 | |
| 8 | José Torres# | 12.38 | 2029 | |
| 9 | Dan White | 12.31 | 2019 | |
| 10 | Archie Esparza# | 12.27 | 2030 | |
| 11 | Bob Jenkins* | 12.00 | 2015 | |
| 11 | Red Amelung | 12.00 | 2014 | |
| 13 | Ronald Moyer# | 11.84 | 2031 | |
| 14 | John Smoltz | 11.53 | 1989 | |
| 15 | Jake McGee | 11.51 | 2017 | |
| 16 | Paul Hale# | 11.49 | 2026 | |
| 17 | Chris Sharp# | 11.40 | 2030 | |
| 18 | Austin Willis | 11.34 | 2021 | |
| 18 | Leo Erickson# | 11.34 | 2028 | |
| 20 | Archie Esparza# | 11.33 | 2031 | |
| 21 | Randy D Johnson | 11.31 | 1994 | |
| 22 | José Torres# | 11.27 | 2030 | |
| 23 | Ed Anderson | 11.25 | 2018 | |
| 24 | Lee Myers# | 11.19 | 2023 | |
| 25 | Raimondo Amberezzio# | 11.03 | 2031 | |
| 26 | James Ryan# | 10.93 | 2021 | |
| 27 | Gerrit Cole# | 10.89 | 2025 | |
| 28 | Scott Kazmir | 10.80 | 2008 | |
| 28 | Mark Prior* | 10.80 | 2003 | |
| 30 | Javier Vazquez* | 10.64 | 2004 | |
| 31 | Dwight Tucker | 10.61 | 2015 | |
| 32 | Bryan Kent# | 10.59 | 2027 | |
| 33 | Roger Clemens* | 10.52 | 1992 | |
| 34 | Bob Frazier# | 10.50 | 2020 | |
| 34 | Máximo Sánchez | 10.50 | 2023 | |
| 36 | Johan Santana | 10.47 | 2014 | |
| 37 | Scott Sanders | 10.46 | 2001 | |
| 38 | Randy D Johnson | 10.44 | 1991 | |
| 39 | Roger Clemens* | 10.35 | 1997 | |
| 40 | Brian Wilson | 10.20 | 2016 | |
| 40 | Gabe Johnson | 10.20 | 2022 | |
| 40 | António Negrón | 10.20 | 2023 | |
| 40 | Ed Anderson | 10.20 | 2021 | |
| 44 | Iván Vargas# | 10.19 | 2026 | |
| 45 | Alfredo Huerta# | 10.16 | 2023 | |
| 46 | Carlos Durán# | 10.12 | 2029 | |
| 47 | Doug Jones | 10.06 | 2015 | |
| 47 | Brad Cochran | 10.06 | 2022 | |
| 49 | Alfredo Huerta# | 10.05 | 2022 | |
| 50 | Kevin Schaefer | 10.04 | 2016 | |
| 50 | Steve Nebraska | 10.04 | 2012 | |
| 52 | Randy D Johnson | 9.97 | 1992 | |
| 53 | Bob Richardson# | 9.72 | 2030 | |
| 54 | Scott Kazmir | 9.71 | 2012 | |
| 55 | Kyle Jones | 9.70 | 2017 | |
| 55 | Andy Ashby | 9.70 | 1996 | |
| 57 | Javier Vazquez* | 9.67 | 2001 | |
| 58 | Shelby Miller | 9.64 | 2022 | |
| 58 | Tim Pulliam# | 9.64 | 2028 | |
| 58 | Ugueth Urbina | 9.64 | 2000 | |
| 61 | Stephen Strasburg | 9.63 | 2016 | |
| 62 | William Pierce# | 9.62 | 2025 | |
| 63 | Jake Peavy | 9.60 | 2008 | |
| 64 | Bob Jenkins* | 9.57 | 2014 | |
| 65 | Fred Hawkins | 9.55 | 2020 | |
| 65 | Steve Karsay | 9.55 | 1995 | |
| 67 | Javier Vazquez* | 9.53 | 2003 | |
| 67 | Carlos E Hernandez | 9.53 | 2002 | |
| 69 | Jon Lester | 9.50 | 2013 | |
| 70 | Roger Clemens* | 9.49 | 1990 | |
| 71 | Roberto Sánchez# | 9.39 | 2028 | |
| 71 | Chad Ogea | 9.39 | 2001 | |
| 73 | Jason Dickson | 9.37 | 2001 | |
| 74 | Jeff Shoemaker# | 9.35 | 2029 | |
| 74 | Kevin Millwood | 9.35 | 2001 | |
| 76 | Manuel Vázquez# | 9.31 | 2028 | |
| 76 | Raúl Mateo# | 9.31 | 2027 | |
| 78 | Avery Webb# | 9.28 | 2022 | |
| 78 | Kyle Sackett | 9.28 | 2006 | |
| 80 | Tommy Austin | 9.20 | 2017 | |
| 81 | Roger Clemens* | 9.19 | 1994 | |
| 81 | Johan Santana | 9.19 | 2008 | |
| 83 | George Williams# | 9.18 | 2026 | |
| 83 | Eldon Hernández | 9.18 | 2022 | |
| 85 | Rich Burton | 9.17 | 2021 | |
| 85 | Tim Lincecum | 9.17 | 2020 | |
| 87 | Luis Anguiana# | 9.16 | 2027 | |
| 88 | Juan Velázquez# | 9.15 | 2030 | |
| 89 | Roberto Sánchez# | 9.14 | 2030 | |
| 89 | Mark Buehrle | 9.14 | 2003 | |
| 91 | Malcolm Zegwaard | 9.13 | 2014 | |
| 92 | Carlos Durán# | 9.12 | 2028 | |
| 93 | Kumar Rocker# | 9.11 | 2022 | |
| 94 | James Ryan# | 9.00 | 2025 | |
| 94 | Felix Hernandez | 9.00 | 2011 | |
| 94 | Matt J Miller | 9.00 | 2005 | |
| 94 | Benny Howard# | 9.00 | 2023 | |
| 94 | Heath Bell | 9.00 | 2009 | |
| 94 | Bob Jenkins* | 9.00 | 2019 | |
| 94 | Archie Esparza# | 9.00 | 2025 |
