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| League History Index | Players | Teams | Managers | Leagues | Leaderboards | Awards | Accomplishments |
| Rank | Player | IP | YEAR | Open Postseason Career Leaderboard |
|---|---|---|---|---|
| 1 | Daron Maddox | 52.0 | 2017 | |
| 2 | Joba Chamberlain | 51.0 | 2022 | |
| 3 | Lee Myers# | 50.0 | 2028 | |
| 4 | Jason Ellis | 48.0 | 2016 | |
| 5 | Stephen Strasburg | 47.0 | 2016 | |
| 5 | Mark Mulder | 47.0 | 2005 | |
| 5 | Roger Powell | 47.0 | 2022 | |
| 8 | Madison Bumgarner | 46.0 | 2023 | |
| 8 | Lee Myers# | 46.0 | 2026 | |
| 10 | Roy Ward | 45.0 | 2017 | |
| 11 | Jason Ellis | 44.0 | 2020 | |
| 11 | Zack Greinke* | 44.0 | 2010 | |
| 13 | Matt Morris | 43.0 | 2000 | |
| 13 | Daniel Patterson | 43.0 | 2022 | |
| 13 | CC Sabathia* | 43.0 | 2006 | |
| 13 | Roger Clemens* | 43.0 | 1998 | |
| 13 | Alfredo Huerta# | 43.0 | 2022 | |
| 13 | José Torres# | 43.0 | 2028 | |
| 19 | Eddie Morgan* | 41.0 | 2011 | |
| 19 | Jose Acevedo | 41.0 | 2004 | |
| 19 | Rich Burton | 41.0 | 2022 | |
| 19 | Gilberto Martínez# | 41.0 | 2029 | |
| 23 | Brandon Webb* | 40.0 | 2018 | |
| 23 | CC Sabathia* | 40.0 | 2004 | |
| 23 | Roy Oswalt* | 40.0 | 2013 | |
| 26 | Dan Woods# | 39.0 | 2028 | |
| 26 | Jim Anderson# | 39.0 | 2022 | |
| 28 | Bob Jenkins* | 38.0 | 2018 | |
| 28 | Reece MacKinley | 38.0 | 2014 | |
| 28 | José Torres# | 38.0 | 2030 | |
| 28 | Ryan Arnold | 38.0 | 2012 | |
| 28 | Jeff Sawyer | 38.0 | 2007 | |
| 28 | Chip Blake# | 38.0 | 2025 | |
| 34 | A J Burnett | 37.0 | 2002 | |
| 34 | Javier Vazquez* | 37.0 | 2005 | |
| 34 | Brett Tomko | 37.0 | 2000 | |
| 37 | Eric Hillman | 36.0 | 2002 | |
| 37 | Bob Jenkins* | 36.0 | 2014 | |
| 37 | Reece MacKinley | 36.0 | 2015 | |
| 37 | Archie Esparza# | 36.0 | 2030 | |
| 37 | Austin Willis | 36.0 | 2024 | |
| 37 | Cole Hamels* | 36.0 | 2013 | |
| 37 | Chad Billingsley | 36.0 | 2011 | |
| 37 | Dick Hulse | 36.0 | 2015 | |
| 37 | Fred Hawkins | 36.0 | 2022 | |
| 46 | Aaron Sele* | 35.0 | 2003 | |
| 46 | George Connolly# | 35.0 | 2025 | |
| 46 | Zack Greinke* | 35.0 | 2018 | |
| 46 | Raimondo Amberezzio# | 35.0 | 2030 | |
| 46 | Roger Clemens* | 35.0 | 1997 | |
| 46 | Jon Lieber | 35.0 | 2002 | |
| 46 | Roy Oswalt* | 35.0 | 2011 | |
| 46 | Toki Nagai | 35.0 | 2012 | |
| 46 | Daniel Patterson | 35.0 | 2025 | |
| 46 | Jerry Patterson | 35.0 | 2012 | |
| 56 | Madison Bumgarner | 34.0 | 2028 | |
| 56 | Jeff Shoemaker# | 34.0 | 2029 | |
| 56 | Chip Blake# | 34.0 | 2024 | |
| 56 | John Halama | 34.0 | 2007 | |
| 56 | George Connolly# | 34.0 | 2021 | |
| 56 | Jon Lieber | 34.0 | 2007 | |
| 56 | Bob Jenkins* | 34.0 | 2016 | |
| 56 | Joba Chamberlain | 34.0 | 2018 | |
| 56 | Noah Lowry | 34.0 | 2007 | |
| 65 | George Connolly# | 33.0 | 2024 | |
| 65 | Tim Pulliam# | 33.0 | 2029 | |
| 65 | Ken Brandon | 33.0 | 2022 | |
| 65 | Ismael Valdez* | 33.0 | 2002 | |
| 65 | Andy Ashby | 33.0 | 2000 | |
| 65 | Gary Lefebvre | 33.0 | 2013 | |
| 65 | Steve Karsay | 33.0 | 1995 | |
| 65 | Bob Jenkins* | 33.0 | 2015 | |
| 65 | Javier Vazquez* | 33.0 | 2004 | |
| 74 | Jason Dickson | 32.0 | 2001 | |
| 74 | Scott Sanders | 32.0 | 2004 | |
| 74 | Allen Bailey | 32.0 | 2013 | |
| 74 | Kent Bottenfield | 32.0 | 1999 | |
| 74 | Bob Wolcott | 32.0 | 1999 | |
| 74 | Tim Lincecum | 32.0 | 2009 | |
| 74 | Kyle Sackett | 32.0 | 2006 | |
| 74 | Jimmy Anderson | 32.0 | 2006 | |
| 74 | Jerry Patterson | 32.0 | 2009 | |
| 74 | John Smoltz | 32.0 | 1989 | |
| 74 | Avery Webb# | 32.0 | 2022 | |
| 74 | Jesús Bravo# | 32.0 | 2028 | |
| 74 | John Smoltz | 32.0 | 1999 | |
| 87 | Roy Halladay* | 31.0 | 2006 | |
| 87 | Chris Carpenter | 31.0 | 2006 | |
| 87 | Roger Clemens* | 31.0 | 1992 | |
| 87 | Chad Billingsley | 31.0 | 2016 | |
| 87 | Roger Clemens* | 31.0 | 1994 | |
| 87 | Randy Wolf | 31.0 | 2012 | |
| 87 | Roy Ward | 31.0 | 2023 | |
| 87 | Jeff Shoemaker# | 31.0 | 2031 | |
| 87 | Roy Halladay* | 31.0 | 2002 | |
| 87 | Alfredo Huerta# | 31.0 | 2023 | |
| 87 | Joba Chamberlain | 31.0 | 2016 | |
| 87 | Raimondo Amberezzio# | 31.0 | 2031 | |
| 99 | Eduard Fotachi# | 30.0 | 2029 | |
| 99 | Javier Vazquez* | 30.0 | 2006 |
