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| League History Index | Players | Teams | Managers | Leagues | Leaderboards | Awards | Accomplishments |
| Rank | Player | HR | YEAR | Open Season Leaderboard |
|---|---|---|---|---|
| 1 | Rafael Palmeiro* | 639 | 1986-2007 | |
| 2 | Donovan Brown# | 406 | 2014-2030 | |
| 3 | Jack Cust | 366 | 2001-2013 | |
| 4 | Kal Daniels* | 318 | 1986-2003 | |
| 5 | Paul Shaw* | 299 | 2003-2014 | |
| 6 | Christian Yelich# | 285 | 2020-2031 | |
| 7 | Pablo Martínez# | 284 | 2022-2031 | |
| 8 | Adam Dunn | 277 | 2001-2010 | |
| 8 | Troy Morgan | 277 | 2008-2022 | |
| 10 | Miguel Cabrera | 270 | 2004-2014 | |
| 11 | Eric Anthony* | 247 | 1989-2004 | |
| 12 | Pat McJannett | 245 | 2011-2019 | |
| 13 | Duane Green | 243 | 2009-2018 | |
| 14 | Jimmy Tenace# | 232 | 2022-2031 | |
| 15 | Carlos Lee | 225 | 1999-2008 | |
| 16 | Jaime Nava# | 224 | 2021-2031 | |
| 17 | Juan Rivera | 222 | 2001-2013 | |
| 18 | Júlio Valverde | 221 | 2006-2018 | |
| 19 | Albert Belle | 218 | 1989-2002 | |
| 20 | Tony Cabrera | 214 | 2010-2022 | |
| 21 | Reggie L Sanders | 212 | 1991-2003 | |
| 22 | Karim Garcia | 205 | 1997-2008 | |
| 22 | Tom Godwin | 205 | 2012-2027 | |
| 24 | Pedro Delgado# | 202 | 2023-2031 | |
| 25 | Jon Nunnally | 198 | 1995-2005 | |
| 26 | Brad Curry# | 191 | 2022-2031 | |
| 27 | Todd Hollandsworth | 190 | 1995-2007 | |
| 28 | Greg Byrd# | 186 | 2023-2031 | |
| 29 | Ryan Klesko | 185 | 1992-2006 | |
| 30 | Jon Coleman | 179 | 2016-2026 | |
| 31 | Andre Ethier | 176 | 2008-2022 | |
| 31 | Paul Konerko* | 176 | 1997-2014 | |
| 33 | Carlos Delgado | 174 | 1993-2001 | |
| 33 | Brad Wilkerson | 174 | 2001-2012 | |
| 35 | Dan Carlson | 172 | 2016-2025 | |
| 36 | Santiago Prado# | 170 | 2019-2031 | |
| 37 | David Schneider | 169 | 2010-2021 | |
| 37 | Roy Thomas | 169 | 2011-2017 | |
| 39 | A.R. Cross | 166 | 2013-2021 | |
| 40 | Christopher Taylor | 160 | 2006-2012 | |
| 41 | Pedro Munoz* | 159 | 1990-2006 | |
| 42 | Marty Cordova | 156 | 1995-2005 | |
| 42 | Jim Jones# | 156 | 2020-2031 | |
| 42 | Fernando Seguignol | 156 | 1998-2006 | |
| 45 | Ray Sheffield | 150 | 2000-2012 | |
| 46 | Hideki Matsui | 149 | 2005-2016 | |
| 47 | Chris Becker | 148 | 2014-2022 | |
| 48 | Troy Neel | 147 | 1992-2003 | |
| 49 | Xavier Nady | 145 | 2001-2013 | |
| 50 | Vicente Valdéz# | 144 | 2027-2031 | |
| 51 | Eloy Jimenez# | 141 | 2024-2031 | |
| 51 | Mike Martin | 141 | 2015-2023 | |
| 53 | Al L Martin | 138 | 1992-2002 | |
| 54 | Jason Giambi | 134 | 1995-2008 | |
| 54 | Carlos Hernández# | 134 | 2022-2029 | |
| 54 | David Malone# | 134 | 2021-2028 | |
| 54 | Matt Watts | 134 | 2010-2019 | |
| 58 | Mike Taylor# | 133 | 2021-2031 | |
| 59 | Art Looper | 132 | 2018-2030 | |
| 59 | Stanley Rush | 132 | 2009-2017 | |
| 61 | Jerry Monroe | 131 | 2008-2015 | |
| 62 | Joe Turner# | 128 | 2017-2027 | |
| 63 | Will Myers | 127 | 2001-2011 | |
| 64 | Howard Graves | 126 | 2009-2015 | |
| 65 | David Summers# | 124 | 2024-2030 | |
| 66 | Cliff Floyd | 123 | 1993-2007 | |
| 67 | B.J. MacFadden | 122 | 2015-2025 | |
| 68 | Matt Holliday | 121 | 2004-2010 | |
| 69 | Esteban Navarro | 120 | 2009-2022 | |
| 69 | James Wilkins# | 120 | 2021-2031 | |
| 71 | Tim Brewer | 119 | 2008-2020 | |
| 72 | John Vander Wal | 118 | 1991-2001 | |
| 73 | Errol Calhoun | 117 | 2017-2028 | |
| 74 | Garret Anderson | 115 | 1994-2003 | |
| 74 | Lance Berkman | 115 | 1999-2010 | |
| 74 | Ed Harris | 115 | 2001-2010 | |
| 74 | Jason Jones | 115 | 2005-2010 | |
| 78 | Brooks Kieschnick | 114 | 1996-2008 | |
| 78 | Jorge Ruíz | 114 | 2004-2018 | |
| 80 | Daryle Ward | 111 | 1998-2003 | |
| 81 | Pedro Cerrano | 110 | 2009-2020 | |
| 81 | Kenny Evans | 110 | 2001-2011 | |
| 83 | Gilbert Taylor# | 109 | 2020-2029 | |
| 84 | Ken Phillips | 107 | 2010-2022 | |
| 85 | Brian Short | 104 | 2008-2017 | |
| 86 | Travis Fletcher | 101 | 2010-2020 | |
| 86 | Mitsuharu Suzuki# | 101 | 2026-2031 | |
| 88 | Ronald Benjamin | 98 | 2016-2025 | |
| 89 | Martin Davidson | 95 | 2019-2023 | |
| 89 | Miguel García | 95 | 2005-2009 | |
| 89 | Kazuma Yamaguchi# | 95 | 2028-2031 | |
| 92 | Bobby Higginson | 94 | 1995-2004 | |
| 93 | Damon Howell | 93 | 2017-2026 | |
| 93 | Robbie Kelley | 93 | 2021-2025 | |
| 95 | Ryan Church | 91 | 2005-2010 | |
| 95 | Jamy Gouloze# | 91 | 2028-2031 | |
| 97 | John Emerson | 89 | 2008-2020 | |
| 98 | Larry Castillo# | 87 | 2025-2031 | |
| 98 | Shane Spencer | 87 | 1998-2004 | |
| 100 | Lew Ford | 86 | 2004-2013 |
