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| League History Index | Players | Teams | Managers | Leagues | Leaderboards | Awards | Accomplishments |
| Rank | Player | K | YEAR | Open Season Leaderboard |
|---|---|---|---|---|
| 1 | Roger Clemens* | 4943 | 1984-2006 | |
| 2 | Josh Beckett* | 3095 | 2001-2020 | |
| 3 | Cole Hamels* | 3086 | 2007-2023 | |
| 4 | Bob Jenkins* | 2988 | 2008-2023 | |
| 5 | Mark Prior* | 2973 | 2002-2016 | |
| 6 | Scott Sanders | 2856 | 1993-2007 | |
| 7 | Randy D Johnson | 2799 | 1988-2003 | |
| 8 | Dwight Tucker | 2774 | 2011-2027 | |
| 9 | Javier Vazquez* | 2756 | 1998-2013 | |
| 10 | Jorge Enríquez# | 2748 | 2020-2031 | |
| 11 | Brandon Webb* | 2740 | 2004-2024 | |
| 12 | John Smoltz | 2688 | 1988-2003 | |
| 13 | Juan Guzman* | 2684 | 1991-2005 | |
| 14 | Stephen Strasburg | 2663 | 2011-2027 | |
| 15 | CC Sabathia* | 2575 | 2001-2019 | |
| 16 | Tim Lincecum | 2559 | 2009-2025 | |
| 17 | Madison Bumgarner | 2552 | 2014-2031 | |
| 17 | David Nied* | 2552 | 1992-2009 | |
| 19 | Johan Santana | 2498 | 2000-2015 | |
| 20 | Ismael Valdez* | 2481 | 1994-2010 | |
| 21 | Brett Myers | 2424 | 2002-2017 | |
| 22 | Steve Karsay | 2347 | 1993-2007 | |
| 23 | Zack Greinke* | 2343 | 2005-2020 | |
| 24 | Gary Lefebvre | 2336 | 2002-2016 | |
| 25 | Major Pixel | 2328 | 2007-2021 | |
| 26 | Eddie Morgan* | 2265 | 2005-2019 | |
| 27 | Lee Myers# | 2219 | 2019-2031 | |
| 28 | Gilberto Martínez# | 2213 | 2025-2031 | |
| 29 | Scott Kazmir | 2207 | 2004-2019 | |
| 30 | Aaron Sele* | 2204 | 1993-2006 | |
| 31 | Joba Chamberlain | 2191 | 2012-2027 | |
| 31 | Eduard Fotachi# | 2191 | 2019-2031 | |
| 33 | Allen Bailey | 2179 | 2011-2023 | |
| 34 | Kerry Wood | 2155 | 1998-2007 | |
| 35 | Matthew Trantham | 2152 | 2015-2029 | |
| 36 | Andy Ashby | 2132 | 1991-2002 | |
| 37 | Chad Billingsley | 2110 | 2008-2024 | |
| 38 | R A Dickey | 2106 | 2002-2018 | |
| 39 | Jerry Burrell# | 2093 | 2016-2031 | |
| 40 | Reece MacKinley | 2086 | 2007-2024 | |
| 41 | Carlos Zambrano | 2060 | 2001-2019 | |
| 42 | James Ryan# | 2057 | 2017-2027 | |
| 43 | Kyle Sackett | 2036 | 2000-2015 | |
| 44 | George Connolly# | 2035 | 2018-2031 | |
| 45 | Roy Ward | 2022 | 2014-2026 | |
| 46 | Paul Hale# | 2021 | 2020-2031 | |
| 47 | Randy Wolf | 2017 | 1999-2013 | |
| 48 | Gil Meche | 2013 | 1999-2014 | |
| 49 | Raúl López | 2006 | 2000-2016 | |
| 50 | Ronald Moyer# | 1983 | 2023-2031 | |
| 51 | Nolan Arnold | 1978 | 2011-2022 | |
| 51 | Roy Oswalt* | 1978 | 2001-2016 | |
| 53 | Michael Hood | 1959 | 2002-2013 | |
| 54 | Jon Lieber | 1956 | 1994-2009 | |
| 55 | A J Burnett | 1946 | 1999-2010 | |
| 56 | Jake Peavy | 1939 | 2002-2017 | |
| 57 | Heath Bell | 1934 | 2004-2021 | |
| 57 | Steve Nebraska | 1934 | 2005-2018 | |
| 59 | Bartolo Colon | 1905 | 1997-2011 | |
| 60 | Ramon J Martinez | 1900 | 1988-2002 | |
| 61 | Daron Maddox | 1877 | 2015-2027 | |
| 62 | Miguel Moreno# | 1871 | 2020-2031 | |
| 63 | Alex Fernandez | 1853 | 1990-2004 | |
| 64 | Roy Halladay* | 1851 | 1998-2014 | |
| 65 | Kevin Millwood | 1846 | 1997-2011 | |
| 66 | Adam Wainwright | 1833 | 2009-2024 | |
| 67 | Eric Hurley | 1825 | 2007-2020 | |
| 68 | Barry Zito | 1814 | 2000-2014 | |
| 69 | Brandon Duckworth | 1809 | 2001-2011 | |
| 70 | Victor Dunlap | 1803 | 2010-2020 | |
| 71 | Steve Woodard | 1801 | 1997-2014 | |
| 72 | Rick Ankiel | 1787 | 1999-2015 | |
| 73 | Chris Carpenter | 1769 | 1997-2009 | |
| 74 | Keith McCoy# | 1756 | 2020-2031 | |
| 75 | Archie Esparza# | 1751 | 2025-2031 | |
| 76 | Ben Sheets | 1741 | 2001-2015 | |
| 77 | Alan Benes | 1737 | 1995-2006 | |
| 78 | Dick Hulse | 1736 | 2009-2021 | |
| 79 | Pedro López# | 1732 | 2019-2031 | |
| 80 | Gregory Burke | 1720 | 2002-2013 | |
| 81 | Bill Gill# | 1713 | 2023-2031 | |
| 82 | Wade Miller | 1709 | 1999-2012 | |
| 83 | Rheal Cormier | 1705 | 1991-2005 | |
| 84 | Gabe Johnson | 1698 | 2019-2028 | |
| 85 | Hideo Nomo | 1681 | 1995-2003 | |
| 86 | Joe Sparks | 1661 | 2007-2019 | |
| 87 | Roger Bailey | 1659 | 2003-2014 | |
| 88 | Angel Miranda | 1656 | 1993-2006 | |
| 89 | Josh England | 1651 | 2008-2019 | |
| 90 | Jeff Samardzija | 1645 | 2009-2021 | |
| 91 | Jason Ellis | 1644 | 2013-2027 | |
| 92 | Chris R Young | 1641 | 2004-2016 | |
| 93 | Willie E Adams | 1640 | 1996-2008 | |
| 94 | Matt Beech | 1632 | 1996-2005 | |
| 95 | Joe Mays | 1612 | 1999-2011 | |
| 96 | Manuel Vázquez# | 1611 | 2024-2031 | |
| 97 | Dave Pownall | 1610 | 2014-2027 | |
| 98 | Paul Phelps | 1607 | 2014-2026 | |
| 99 | Anthony Hunt | 1601 | 2016-2028 | |
| 100 | Máximo Sánchez | 1596 | 2015-2025 |
