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| League History Index | Players | Teams | Managers | Leagues | Leaderboards | Awards | Accomplishments |
| Rank | Player | GS | YEAR | Open Season Leaderboard |
|---|---|---|---|---|
| 1 | Roger Clemens* | 653 | 1984-2006 | |
| 2 | Josh Beckett* | 609 | 2001-2020 | |
| 3 | Brandon Webb* | 604 | 2004-2024 | |
| 4 | David Nied* | 581 | 1992-2009 | |
| 5 | Hipolito Pichardo | 529 | 1992-2008 | |
| 6 | Brett Myers | 500 | 2002-2017 | |
| 7 | Cole Hamels* | 497 | 2007-2023 | |
| 8 | CC Sabathia* | 491 | 2001-2019 | |
| 9 | Steve Karsay | 485 | 1993-2007 | |
| 10 | John Smoltz | 478 | 1988-2003 | |
| 10 | Ismael Valdez* | 478 | 1994-2010 | |
| 12 | Reece MacKinley | 476 | 2007-2024 | |
| 13 | Madison Bumgarner | 475 | 2014-2031 | |
| 14 | Scott Sanders | 471 | 1993-2007 | |
| 15 | Gil Meche | 468 | 1999-2014 | |
| 16 | Zack Greinke* | 466 | 2005-2020 | |
| 17 | Tim Lincecum | 449 | 2009-2025 | |
| 18 | Randy Tomlin | 447 | 1990-2005 | |
| 18 | Dwight Tucker | 447 | 2011-2027 | |
| 20 | Jon Lieber | 445 | 1994-2009 | |
| 20 | Roy Oswalt* | 445 | 2001-2016 | |
| 22 | Matthew Trantham | 444 | 2015-2029 | |
| 23 | Chad Billingsley | 438 | 2008-2024 | |
| 23 | Eddie Morgan* | 438 | 2005-2019 | |
| 25 | Bob Jenkins* | 433 | 2008-2023 | |
| 26 | Juan Guzman* | 432 | 1991-2005 | |
| 27 | Bartolo Colon | 430 | 1997-2011 | |
| 28 | Kyle Sackett | 428 | 2000-2015 | |
| 29 | Mark Prior* | 426 | 2002-2016 | |
| 29 | Javier Vazquez* | 426 | 1998-2013 | |
| 31 | Carl Pavano | 425 | 1998-2012 | |
| 32 | Johan Santana | 421 | 2000-2015 | |
| 33 | Joba Chamberlain | 419 | 2012-2027 | |
| 33 | Rheal Cormier | 419 | 1991-2005 | |
| 35 | Roy Halladay* | 418 | 1998-2014 | |
| 36 | Allen Bailey | 416 | 2011-2023 | |
| 37 | Stephen Strasburg | 413 | 2011-2027 | |
| 38 | George Connolly# | 408 | 2018-2031 | |
| 39 | Gary Lefebvre | 405 | 2002-2016 | |
| 40 | Simon Duncombe | 403 | 2002-2017 | |
| 41 | Aaron Sele* | 400 | 1993-2006 | |
| 42 | R A Dickey | 393 | 2002-2018 | |
| 42 | Eric Hurley | 393 | 2007-2020 | |
| 42 | Randy Wolf | 393 | 1999-2013 | |
| 45 | Jerry Burrell# | 392 | 2016-2031 | |
| 45 | Ramon J Martinez | 392 | 1988-2002 | |
| 47 | Brad Radke | 389 | 1995-2007 | |
| 48 | Ryan Bowen | 388 | 1992-2005 | |
| 49 | Andy Ashby | 387 | 1991-2002 | |
| 49 | Ignacio Rodríguez | 387 | 2002-2015 | |
| 49 | Adam Wainwright | 387 | 2009-2024 | |
| 52 | Roy Ward | 385 | 2014-2026 | |
| 52 | Chris R Young | 385 | 2004-2016 | |
| 54 | Kevin Millwood | 383 | 1997-2011 | |
| 55 | Jason Ellis | 382 | 2013-2027 | |
| 56 | Randy D Johnson | 381 | 1988-2003 | |
| 57 | Matt Cain | 380 | 2007-2020 | |
| 58 | Carlos Zambrano | 375 | 2001-2019 | |
| 59 | Raúl López | 371 | 2000-2016 | |
| 60 | Tom Glavine | 368 | 1987-2003 | |
| 60 | Lee Myers# | 368 | 2019-2031 | |
| 62 | Major Pixel | 362 | 2007-2021 | |
| 63 | Jorge Enríquez# | 361 | 2020-2031 | |
| 64 | Steve Nebraska | 360 | 2005-2018 | |
| 65 | Brandon Duckworth | 359 | 2001-2011 | |
| 65 | Alex Fernandez | 359 | 1990-2004 | |
| 65 | Joe Mays | 359 | 1999-2011 | |
| 68 | A J Burnett | 355 | 1999-2010 | |
| 68 | Chris Carpenter | 355 | 1997-2009 | |
| 70 | Nolan Arnold | 354 | 2011-2022 | |
| 70 | Dick Hulse | 354 | 2009-2021 | |
| 72 | Joey Hamilton | 348 | 1994-2007 | |
| 73 | Aaron Harang | 346 | 2003-2017 | |
| 73 | Barry Zito | 346 | 2000-2014 | |
| 75 | Paul Phelps | 344 | 2014-2026 | |
| 76 | Pedro López# | 343 | 2019-2031 | |
| 77 | Jimmy Anderson | 342 | 1999-2011 | |
| 78 | Cliff P Lee | 341 | 2003-2015 | |
| 79 | Manny Aybar | 339 | 1997-2008 | |
| 79 | Bob Clark | 339 | 2001-2015 | |
| 79 | Jake Peavy | 339 | 2002-2017 | |
| 82 | Josh England | 338 | 2008-2019 | |
| 83 | Jerry Patterson | 336 | 2002-2015 | |
| 83 | Steve Woodard | 336 | 1997-2014 | |
| 85 | Alan Benes | 335 | 1995-2006 | |
| 85 | Austin Braden | 335 | 2007-2018 | |
| 85 | Scott Kazmir | 335 | 2004-2019 | |
| 88 | Mark Jones | 330 | 2009-2021 | |
| 89 | Michael Hood | 329 | 2002-2013 | |
| 90 | Julián Martínez | 324 | 2007-2019 | |
| 90 | Jeff Samardzija | 324 | 2009-2021 | |
| 92 | Eduard Fotachi# | 323 | 2019-2031 | |
| 93 | Dave Márquez | 322 | 2017-2029 | |
| 94 | Chad Ogea | 321 | 1994-2007 | |
| 95 | Willie E Adams | 318 | 1996-2008 | |
| 96 | Roger Bailey | 317 | 2003-2014 | |
| 97 | Rich Burton | 316 | 2018-2030 | |
| 97 | David Stevens | 316 | 2019-2030 | |
| 99 | Toki Nagai | 315 | 2004-2015 | |
| 99 | Ben Sheets | 315 | 2001-2015 |
