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| League History Index | Players | Teams | Managers | Leagues | Leaderboards | Awards | Accomplishments |
| Rank | Player | G | YEAR | Open Season Leaderboard |
|---|---|---|---|---|
| 1 | Kelvim Escobar | 1485 | 1997-2018 | |
| 2 | Wilford Chambers* | 1205 | 2006-2025 | |
| 3 | Santiago Herrera | 1190 | 2000-2018 | |
| 4 | Juan Rincon | 1151 | 2001-2017 | |
| 5 | Rusty Meacham | 1137 | 1991-2006 | |
| 6 | Cory Lidle | 1097 | 1997-2010 | |
| 7 | Terrell Wade | 1096 | 1995-2010 | |
| 8 | George Sherrill | 1095 | 2005-2021 | |
| 9 | Jeff Juden | 1090 | 1991-2009 | |
| 10 | Scott Randall | 1082 | 2003-2020 | |
| 11 | Larry Thomas | 1075 | 1995-2010 | |
| 12 | Mike Harkey | 1063 | 1988-2004 | |
| 13 | Chad Qualls | 1055 | 2006-2020 | |
| 14 | Brad Clontz | 1009 | 1995-2009 | |
| 15 | Jesús Enríquez | 1004 | 2001-2015 | |
| 16 | Mo Sanford | 998 | 1991-2005 | |
| 17 | Aquilino Lopez | 989 | 2005-2019 | |
| 18 | Danny Patterson | 986 | 1996-2010 | |
| 19 | Dicky Gonzalez | 981 | 2001-2018 | |
| 20 | Heath Bell | 980 | 2004-2021 | |
| 21 | Rafael Betancourt | 978 | 2004-2019 | |
| 22 | Brad Lidge | 972 | 2002-2017 | |
| 23 | Dellin Betances | 968 | 2012-2028 | |
| 24 | Rod Beck | 956 | 1991-2004 | |
| 25 | Denny Neagle | 945 | 1991-2005 | |
| 26 | Doug Bochtler | 939 | 1996-2009 | |
| 27 | Lorenzo Barcelo | 935 | 2000-2015 | |
| 28 | Scott Williamson | 914 | 1999-2015 | |
| 29 | Mike V Gonzalez | 913 | 2005-2018 | |
| 30 | Rafael Soriano | 904 | 2002-2013 | |
| 31 | Kiko Calero | 887 | 2004-2019 | |
| 32 | Christian Newall | 885 | 2006-2021 | |
| 33 | Heathcliff Slocumb | 884 | 1991-2005 | |
| 34 | Shane Reynolds | 877 | 1992-2005 | |
| 35 | Jose Melendez | 868 | 1991-2005 | |
| 36 | Francisco Cordova | 863 | 1996-2009 | |
| 36 | Tim Spooneybarger | 863 | 2001-2017 | |
| 38 | Omar Daal | 859 | 1993-2010 | |
| 39 | Greg McMichael | 837 | 1993-2005 | |
| 40 | Billy Koch | 833 | 1999-2010 | |
| 41 | Byung-Hyun Kim | 832 | 1999-2014 | |
| 42 | Tim Davis | 823 | 1994-2009 | |
| 43 | Kevin Gregg | 818 | 2004-2017 | |
| 44 | Trey Moore | 808 | 1998-2010 | |
| 45 | Derek Lowe | 803 | 1997-2007 | |
| 46 | Mariano Rivera | 800 | 1995-2006 | |
| 47 | Scott Atchison | 795 | 2005-2018 | |
| 48 | Clyde Schmidt | 789 | 2011-2022 | |
| 49 | Grant Roberts | 787 | 2000-2013 | |
| 49 | Nathan Whalebelly | 787 | 2015-2029 | |
| 51 | Júlio Pérez | 784 | 2007-2021 | |
| 52 | Graeme Lloyd | 782 | 1993-2005 | |
| 53 | Edwin Jackson | 776 | 2003-2019 | |
| 54 | Jonathan Papelbon | 770 | 2008-2021 | |
| 55 | Craig Kimbrel | 769 | 2010-2025 | |
| 56 | Tom Scott | 768 | 2008-2020 | |
| 57 | Roger Clemens* | 767 | 1984-2006 | |
| 58 | Matt J Miller | 766 | 2003-2016 | |
| 59 | Javier Lopez | 764 | 2005-2017 | |
| 60 | Brian Sikorski | 760 | 2002-2013 | |
| 61 | Scott Elarton | 758 | 1998-2011 | |
| 62 | Charlie Frohwirth | 756 | 2012-2024 | |
| 62 | Pete Young | 756 | 1995-2005 | |
| 64 | Matt White | 754 | 2007-2019 | |
| 65 | Victor Moret | 745 | 2003-2016 | |
| 65 | Tony Saunders | 745 | 1997-2012 | |
| 67 | Steve J Kline | 744 | 1997-2007 | |
| 67 | José Ramírez | 744 | 2003-2018 | |
| 67 | Brian Wilson | 744 | 2007-2021 | |
| 70 | Fernando Cabrera | 735 | 2005-2017 | |
| 70 | Chad Fox | 735 | 1997-2008 | |
| 72 | David Robertson | 734 | 2011-2023 | |
| 73 | Thomas Rice# | 728 | 2017-2031 | |
| 74 | Henry Rowengartner | 727 | 2004-2019 | |
| 75 | Joe Hudson | 725 | 1997-2007 | |
| 76 | Toby Borland | 723 | 1994-2004 | |
| 76 | Sweetbreads Mayer | 723 | 2006-2021 | |
| 78 | Ricardo Rincon | 722 | 1997-2007 | |
| 79 | Yhency Brazoban | 721 | 2007-2017 | |
| 80 | Casey Fossum | 720 | 2001-2013 | |
| 80 | Johnny Garrett | 720 | 2010-2020 | |
| 82 | Jack Bell | 712 | 2009-2020 | |
| 83 | Julio Mateo | 704 | 2003-2014 | |
| 84 | Mike Hampton | 702 | 1994-2009 | |
| 84 | Guillermo Mota | 702 | 1999-2010 | |
| 86 | Rick White | 700 | 1994-2005 | |
| 87 | Mike J Adams | 694 | 2005-2017 | |
| 88 | Eric DuBose | 692 | 2002-2015 | |
| 89 | Chad Gaudin | 689 | 2005-2018 | |
| 90 | Jose A Nunez | 684 | 2001-2012 | |
| 91 | Brendan Donnelly | 683 | 2002-2013 | |
| 92 | Tom Davey | 682 | 1999-2012 | |
| 92 | Joel Hanrahan | 682 | 2009-2021 | |
| 94 | Paco Martínez | 681 | 2002-2011 | |
| 95 | Peter Owen | 678 | 2013-2024 | |
| 96 | Jennie Finch | 677 | 2005-2020 | |
| 97 | Ryan Madson | 675 | 2003-2012 | |
| 98 | Steve Woodard | 671 | 1997-2014 | |
| 99 | Brian Williams | 670 | 2000-2012 | |
| 100 | Roy Burns | 669 | 2001-2011 |
