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| League History Index | Players | Teams | Managers | Leagues | Leaderboards | Awards | Accomplishments |
| Rank | Player | W | YEAR | Open Season Leaderboard |
|---|---|---|---|---|
| 1 | Roger Clemens* | 342 | 1984-2006 | |
| 2 | Brandon Webb* | 276 | 2004-2024 | |
| 3 | Josh Beckett* | 232 | 2001-2020 | |
| 4 | Madison Bumgarner | 231 | 2014-2031 | |
| 5 | CC Sabathia* | 226 | 2001-2019 | |
| 6 | Zack Greinke* | 222 | 2005-2020 | |
| 7 | Bob Jenkins* | 216 | 2008-2023 | |
| 8 | Tim Lincecum | 211 | 2009-2025 | |
| 8 | David Nied* | 211 | 1992-2009 | |
| 10 | Brett Myers | 210 | 2002-2017 | |
| 11 | Cole Hamels* | 209 | 2007-2023 | |
| 12 | Hipolito Pichardo | 207 | 1992-2008 | |
| 13 | Chad Billingsley | 205 | 2008-2024 | |
| 14 | Lee Myers# | 204 | 2019-2031 | |
| 15 | Eddie Morgan* | 201 | 2005-2019 | |
| 16 | George Connolly# | 196 | 2018-2031 | |
| 17 | Juan Guzman* | 195 | 1991-2005 | |
| 17 | Reece MacKinley | 195 | 2007-2024 | |
| 19 | Joba Chamberlain | 193 | 2012-2027 | |
| 19 | Javier Vazquez* | 193 | 1998-2013 | |
| 21 | Roy Oswalt* | 189 | 2001-2016 | |
| 22 | Dwight Tucker | 188 | 2011-2027 | |
| 23 | Ismael Valdez* | 187 | 1994-2010 | |
| 24 | Gil Meche | 186 | 1999-2014 | |
| 24 | Mark Prior* | 186 | 2002-2016 | |
| 26 | John Smoltz | 184 | 1988-2003 | |
| 27 | Scott Sanders | 183 | 1993-2007 | |
| 28 | Jon Lieber | 179 | 1994-2009 | |
| 29 | Stephen Strasburg | 178 | 2011-2027 | |
| 30 | Andy Ashby | 177 | 1991-2002 | |
| 30 | Aaron Sele* | 177 | 1993-2006 | |
| 32 | R A Dickey | 176 | 2002-2018 | |
| 33 | Major Pixel | 174 | 2007-2021 | |
| 34 | Ramon J Martinez | 171 | 1988-2002 | |
| 35 | Jerry Burrell# | 170 | 2016-2031 | |
| 35 | Johan Santana | 170 | 2000-2015 | |
| 37 | Ignacio Rodríguez | 169 | 2002-2015 | |
| 38 | Nolan Arnold | 168 | 2011-2022 | |
| 38 | Allen Bailey | 168 | 2011-2023 | |
| 38 | Rheal Cormier | 168 | 1991-2005 | |
| 41 | Roy Halladay* | 165 | 1998-2014 | |
| 42 | Carlos Zambrano | 163 | 2001-2019 | |
| 43 | Steve Karsay | 161 | 1993-2007 | |
| 43 | Gary Lefebvre | 161 | 2002-2016 | |
| 45 | Jimmy Anderson | 159 | 1999-2011 | |
| 45 | Chris Carpenter | 159 | 1997-2009 | |
| 45 | Jake Peavy | 159 | 2002-2017 | |
| 48 | Anthony Hunt | 158 | 2016-2028 | |
| 49 | Simon Duncombe | 157 | 2002-2017 | |
| 50 | Jorge Enríquez# | 156 | 2020-2031 | |
| 51 | Randy Wolf | 154 | 1999-2013 | |
| 52 | Roy Ward | 153 | 2014-2026 | |
| 53 | Eric Hurley | 152 | 2007-2020 | |
| 53 | Carl Pavano | 152 | 1998-2012 | |
| 55 | Randy D Johnson | 151 | 1988-2003 | |
| 56 | Raúl López | 150 | 2000-2016 | |
| 57 | Randy Tomlin | 148 | 1990-2005 | |
| 57 | Steve Woodard | 148 | 1997-2014 | |
| 59 | Keith McCoy# | 146 | 2020-2031 | |
| 60 | Scott Kazmir | 145 | 2004-2019 | |
| 60 | Kevin Millwood | 145 | 1997-2011 | |
| 62 | Steve Nebraska | 144 | 2005-2018 | |
| 63 | Tom Glavine | 142 | 1987-2003 | |
| 63 | Paul Phelps | 142 | 2014-2026 | |
| 65 | Stan Combs# | 140 | 2023-2031 | |
| 66 | Jason Ellis | 139 | 2013-2027 | |
| 66 | Kevin Schaefer | 139 | 2012-2023 | |
| 68 | Eduard Fotachi# | 138 | 2019-2031 | |
| 68 | Dick Hulse | 138 | 2009-2021 | |
| 70 | Kyle Sackett | 137 | 2000-2015 | |
| 71 | Toki Nagai | 136 | 2004-2015 | |
| 71 | Matthew Trantham | 136 | 2015-2029 | |
| 71 | Adam Wainwright | 136 | 2009-2024 | |
| 74 | A J Burnett | 135 | 1999-2010 | |
| 75 | Matt Cain | 134 | 2007-2020 | |
| 76 | Bob Clark | 133 | 2001-2015 | |
| 77 | Alex Fernandez | 132 | 1990-2004 | |
| 77 | Jerry Patterson | 132 | 2002-2015 | |
| 79 | Gregory Burke | 131 | 2002-2013 | |
| 79 | Josh England | 131 | 2008-2019 | |
| 79 | Aaron Harang | 131 | 2003-2017 | |
| 82 | Brad Radke | 130 | 1995-2007 | |
| 82 | Bud Smith | 130 | 2001-2014 | |
| 84 | Ryan Bowen | 129 | 1992-2005 | |
| 84 | Rich Burton | 129 | 2018-2030 | |
| 84 | Julián Martínez | 129 | 2007-2019 | |
| 87 | Heath Bell | 128 | 2004-2021 | |
| 87 | Mark Jones | 128 | 2009-2021 | |
| 87 | Ben Sheets | 128 | 2001-2015 | |
| 87 | Chris R Young | 128 | 2004-2016 | |
| 91 | Mark Buehrle | 126 | 2000-2016 | |
| 91 | Micah Olson# | 126 | 2016-2031 | |
| 91 | Barry Zito | 126 | 2000-2014 | |
| 94 | Manny Aybar | 125 | 1997-2008 | |
| 94 | Alan Benes | 125 | 1995-2006 | |
| 96 | Noah Lowry | 124 | 2004-2015 | |
| 96 | Angel Miranda | 124 | 1993-2006 | |
| 96 | Ronald Moyer# | 124 | 2023-2031 | |
| 96 | Dave Márquez | 124 | 2017-2029 | |
| 100 | Roger Bailey | 122 | 2003-2014 |
