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| Name | W | L | SV | ERA | G | GS | IP | HA | R | ER | HR | BB | K | WHIP | OAVG | BABIP | WAR |
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| Dave Wolensky RP | 0 | 0 | 0 | 0.00 | 1 | 0 | 1.0 | 2 | 0 | 0 | 0 | 0 | 1 | 2.00 | .400 | .500 | 0.0 |
| Jon Lester SP | 14 | 2 | 0 | 3.02 | 27 | 27 | 164.0 | 129 | 58 | 55 | 8 | 57 | 169 | 1.13 | .211 | .276 | 5.8 |
| Adam Montarbo RP | 6 | 5 | 3 | 3.27 | 49 | 0 | 52.1 | 43 | 21 | 19 | 7 | 17 | 50 | 1.15 | .222 | .263 | 1.0 |
| Richard De Los Santos SP | 9 | 7 | 0 | 3.68 | 25 | 25 | 134.2 | 111 | 57 | 55 | 11 | 61 | 138 | 1.28 | .219 | .279 | 3.2 |
| Joseph Wilson SP | 10 | 8 | 0 | 3.73 | 23 | 23 | 140.0 | 108 | 63 | 58 | 17 | 67 | 142 | 1.25 | .211 | .256 | 2.6 |
| Justin Hampson RP | 5 | 0 | 1 | 3.90 | 48 | 0 | 67.0 | 61 | 29 | 29 | 4 | 31 | 62 | 1.37 | .236 | .295 | 1.3 |
| David Tavarez RP | 1 | 1 | 1 | 4.06 | 44 | 0 | 57.2 | 51 | 28 | 26 | 12 | 33 | 48 | 1.46 | .230 | .241 | -0.7 |
| Justin Sherman SP | 7 | 5 | 0 | 4.21 | 38 | 13 | 107.0 | 106 | 60 | 50 | 18 | 54 | 109 | 1.50 | .255 | .301 | 0.9 |
| Ryan Schwabe SP | 4 | 4 | 0 | 4.22 | 18 | 18 | 96.0 | 93 | 47 | 45 | 13 | 35 | 94 | 1.33 | .252 | .303 | 2.0 |
| Elvys Quezada CL | 7 | 1 | 26 | 4.44 | 49 | 0 | 48.2 | 41 | 26 | 24 | 10 | 28 | 44 | 1.42 | .225 | .240 | -0.6 |
| Jeff Francis RP | 9 | 9 | 0 | 4.48 | 27 | 25 | 128.2 | 123 | 73 | 64 | 13 | 67 | 105 | 1.48 | .249 | .293 | 2.1 |
| Brandon Weeden SP | 1 | 1 | 1 | 4.50 | 43 | 0 | 64.0 | 69 | 35 | 32 | 11 | 31 | 61 | 1.56 | .271 | .312 | -0.1 |
| Mike Megrew SP | 2 | 2 | 2 | 4.82 | 50 | 1 | 61.2 | 51 | 35 | 33 | 5 | 40 | 69 | 1.48 | .227 | .295 | 0.8 |
| Dustin Craig RP | 4 | 4 | 1 | 5.33 | 44 | 0 | 50.2 | 62 | 40 | 30 | 12 | 24 | 50 | 1.70 | .300 | .338 | -0.5 |
| Dan Pohlman RP | 2 | 1 | 0 | 10.69 | 14 | 0 | 16.0 | 27 | 19 | 19 | 6 | 8 | 17 | 2.19 | .360 | .404 | -0.4 |
